2002—2019年上海市长宁区肝癌伤残调整寿命年的趋势分析  

Temporal Trend Analysis of Disability-Adjusted Life Years for Liver Cancer in Changning District of Shanghai,2002—2019

作　　者：吴景 姜玉[5] 毕京浩 周晓慧 张云[5] 张磊[5] 谭玉婷[2,3,4] 夏庆华[5] 赵文穗[5] 项永兵[2,3,4] WU Jing;JIANG Yu;BI Jinghao;ZHOU Xiaohui;ZHANG Yun;ZHANG Lei;TAN Yuting;XIA Qinghua;ZHAO Wensui;XIANG Yongbin(School of Public Health,Shanghai Jiao Tong University,Shanghai 200025,China;State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Epidemiology,Shanghai Cancer Institute,Shanghai 200032,China;Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Shanghai Changning District Center for Disease Control and Prevention,Shanghai 200051,China)

机构地区：[1]上海交通大学公共卫生学院,上海200025 [2]上海交通大学医学院附属仁济医院上海市肿瘤研究所,肿瘤系统医学全国重点实验室,上海200127 [3]上海市肿瘤研究所流行病学研究室,上海200032 [4]上海交通大学医学院附属仁济医院,上海200127 [5]上海市长宁区疾病预防控制中心,上海200051

出　　处：《中国肿瘤》2023年第9期683-690,共8页China Cancer

基　　金：国家重点研发计划项目(2021YFC2500404,2021YFC2500405)。

摘　　要：[目的]分析上海市长宁区居民肝癌的伤残调整寿命年及其变化趋势,为肝癌防治工作提供科学依据。[方法]利用2002—2019年上海市长宁区肿瘤登记数据,估算该地区居民肝癌早死寿命损失年(years of life lost,YLLs)、伤残寿命损失年(years lived with disability,YLDs)和伤残调整寿命年(disability-adjusted life years,DALYs);利用Joinpoint回归模型计算平均年度变化百分比(average annual percentage change,AAPC)和年度变化百分比(annual percentage change,APC),用于分析其时间变化趋势。[结果]2002—2019年长宁区肝癌的DALYs、YLLs、YLDs分别为50080人年、48165人年和1915人年。早死是长宁区肝癌负担的主要原因。DALY、YLL、YLD粗率分别为458.58/10万、441.05/10万和17.54/10万。45岁及以上疾病负担占所有DALYs的90.6%,主要集中在45~69岁,男性疾病负担大于女性。男女合计标化DALY率(AAPC=-4.18%,P<0.05)和标化YLL率(AAPC=-4.36%,P<0.05)整体呈下降趋势,标化YLD率(AAPC=0.46%,P>0.05)保持稳定,且不同性别的变化趋势与整体变化趋势基本一致。[结论]上海市长宁区肝癌的疾病负担呈下降趋势,重点防治对象主要是男性和中老年人群,仍需加强早期筛查和早诊早治工作,进一步降低该地区的肝癌疾病负担。[Purpose]To analyze features and time changes of disability-adjusted life years for primary liver cancer in Changning District of Shanghai from 2002 to 2019.[Methods]Using the cancer registration data of liver cancer in Changning District of Shanghai from 2002 to 2019,the years of life lost(YLLs),years lived with disability(YLDs)and disability-adjusted life years(DALYs)due to premature liver cancer death were estimated.The Joinpoint regression model was used to calculate the average annual percentage change(AAPC)and annual percentage change(APC)to explore time trends in different periods.[Results]The DALYs,YLLs and YLDs of liver cancer in Changning District from 2002 to 2019 were 50080,48165 and 1915 person years,respectively.The premature death was the main cause of liver cancer burden.The crude rates of DALY,YLL and YLD were 458.58/105,441.05/105 and 17.54/105,respectively.The disease burden of people aged 45 years old and over accounted for 90.6%of all DALYs,which was mainly between the ages of 45 and 69 years old.The disease burden in male was higher than that in female.From 2002 to 2019,the age-standardized DALY rates(AAPC=-4.18%,P<0.05)and age-standardized YLL rates(AAPC=-4.36%,P<0.05)of liver cancer in male and female showed an overall downward trend;while the age-standardized YLD rates(AAPC=0.46%,P>0.05)remained stable.The time changes in male and female were basically consistent with the overall trend.[Conclusion]The disease burden of liver cancer in Changning District of Shanghai is showing a decreasing trend.The key prevention and control targets are mainly for males,middle-aged and the elderly population.It is still necessary to strengthen screening,early diagnosis and treatment to further reduce the disease burden of liver cancer in the district.

关 键 词：肝癌 疾病负担 伤残调整寿命年 趋势变化 肿瘤登记 上海 

分 类 号：R735.7[医药卫生—肿瘤]