膀胱副节瘤的临床特征及预后分析  

Clinical features and prognosis of paraganglioma of the urinary bladder

作　　者：杨治立 卢丽雯 张婷[3] 罗文坚 韩彦通 张勇[1] 崔林刚[1] 魏寅生 李腾 孟庆军[1] YANG Zhili;LU Liwen;ZHANG Ting;LUO Wenjian;HAN Yantong;ZHANG Yong;CUI Lingang;WEI Yinsheng;LI Teng;MENG Qingjun(Department of Urology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Thoracic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院泌尿外科,河南郑州450052 [2]郑州大学第一附属医院口腔颌面外科,河南郑州450052 [3]郑州大学第一附属医院胸外科,河南郑州450052

出　　处：《现代泌尿外科杂志》2023年第10期861-866,共6页Journal of Modern Urology

摘　　要：目的探讨膀胱副节瘤(PUB)的临床特征、治疗及预后。方法收集2012年9月—2022年9月在郑州大学第一附属医院就诊且病理诊断明确的41例PUB患者的临床资料,分析其临床特征、手术记录、病理报告、随访记录等,采用Kaplan-Meier法进行生存分析,用Log-rank检验比较组间差异。结果41例患者中,男20例,女21例,中位年龄52岁。患者均接受手术治疗,16例接受经尿道膀胱肿物电切术,23例接受膀胱部分切除术,2例接受膀胱根治性切除术。所有患者均获随访,随访时间4.0~125.0个月,中位随访时间为59.0个月。5例局部复发,5例远处转移。生存分析显示本组病例5年生存率为95.7%,5年无复发生存率为84.8%。进一步分析结果显示,不同肿瘤最大径、生长方式、Ki-67表达状态分组之间的总生存期(OS)及无复发生存期(RFS)差异有统计学意义(P<0.05)。对于肿瘤最大径≤2.8 cm的患者,不同手术分组间的OS及RFS差异无统计学意义。结论PUB较罕见,明确诊断需依据病理,手术治疗为主,预后较好。Objective To explore the clinical features,treatment and prognosis of paraganglioma of the urinary bladder(PUB).Methods The clinical data of 41 PUB patients treated at our hospital during Sep.2012 and Sep.2022 were collected.The clinical features,surgical records,pathological reports and follow-up records were retrospectively analyzed.Patients survival was estimated with Kaplan-Meier estimator.The differences among groups were compared with Log-rank test.Results Among the 41 patients,20 were male and 21 were female,with a median age of 52 years.All patients were treated with surgery,including transurethral resection of bladder tumor(TURBT)in 16 cases,partial cystectomy(PC)in 23 cases,and radical cystectomy(RC)in 2 cases.All patients were followed up for 4.0 to 125.0 months,with a median of 59.0 months.Local recurrence occurred in 5 patients,and distant metastasis occurred in 5 patients.Survival analysis showed that the 5-year overall survival(OS)rate and 5-year relapse-free survival(RFS)rate were 95.7%and 84.8%,respectively.Further analysis showed statistically significant differences in OS and RFS among groups with different maximum tumor diameters,growth patterns,and Ki-67 expressions(P<0.05).For patients with a maximum tumor diameter≤2.8 cm,there was no significant difference in OS and RFS among different surgical groups.Conclusion PUB is rare,and a definitive diagnosis is based on pathology.In addition,the main treatment is surgery and the prognosis is good.

关 键 词：副神经节瘤 膀胱 诊断 治疗 预后 

分 类 号：R739.43[医药卫生—肿瘤]