COVID-19:A pandemic that threatens physical and mental health by promoting physical inactivity  

作　　者：Amira Mohammed Ali Hiroshi Kunugi 

机构地区：[1]Department of Mental Disorder Research,National Institute of Neuroscience,National Center of Neurology and Psychiatry,Tokyo,Japan [2]Department of Psychiatric Nursing and Mental Health,Faculty of Nursing,Alexandria University,Alexandria,Egypt [3]Department of Psychiatry,Teikyo University School of Medicine,Tokyo,Japan

出　　处：《Sports Medicine and Health Science》2020年第4期221-223,共3页运动医学与健康科学（英文）

基　　金：This work was supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development,AMED,Japan(Grant No.18dm0107100h0003).

摘　　要：Ever since the outbreak of Coronavirus disease 2019(COVID-19)in late 2019,it has killed millions of people worldwide.Even people not stricken by this disease are not spared from its negative economic,social,and healthrelated drawbacks.This commentary provides insight into the potential mechanisms involved in the development of depression and emotional negativity escalating during the current pandemic.In particular,preventive measures of COVID-19,such as staying at home,are sedentarism measures that decrease physical activity.Physical inactivity alters gut microbiome structure in a fashion that promotes gut dysbiosis and flaring of systemic inflammation,leading to the buildup of body fat.Obesity,which contributes to a trail of health-depleting disorders,furthers gut microbial disintegration while fat tissue stimulates the release of cytokines,promotes metabolic resistance,and alters signaling involved in the production of antioxidants.As a result,the body gets flooded by toxic molecules such pro-inflammatory mediators,free radicals,and advanced glycation end products.These toxic molecules alter cellular function in all body tissues,including those of the brain.Neuroinflammation is associated with progressive declines in cognitive and motor functions along with dysregulation in emotions.Counteracting the sedentarism enforced by the COVID-19 pandemic through the participation in suitable indoors activities and the intake of healthy food is likely to protect against or revert physiological impairments that may affect people retreating to their homes during the current crisis,eventually restoring physical and mental health.

关 键 词：Coronavirus disease 2019/COVID-19 Severe acute respiratory syndrome-coronavirus-2/SARS-Cov-2 Physical inactivity Obesity Gut microbiome Depression Emotional negativity Inflammation/oxidative stress 

分 类 号：R73[医药卫生—肿瘤]