盘状结构域受体2在肿瘤微环境中的作用研究进展  

Research Progress on Role of Discoidin Domain Receptor 2 in the Tumor Microenvironment

作　　者：李倩倩[1] 李小丽[1] 王变丽 窦文杉 张雯 程龙 张德奎[1] LI Qianqian;LI Xiaoli;WANG Bianli;DOU Wenshan;ZHANG Wen;CHENG Long;ZHANG Dekui(Lanzhou University Second Hospital,Lanzhou 730000,China;Gansu Province Maternal and Child Health Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院,甘肃兰州730000 [2]甘肃省妇幼保健院,甘肃兰州730000

出　　处：《中国肿瘤》2023年第10期773-779,共7页China Cancer

基　　金：国家自然科学基金面上项目(82160111)。

摘　　要：盘状结构域受体2(DDR2)是一种被胶原纤维激活的受体酪氨酸激酶(RTK),近年来研究发现,DDR2在多种肿瘤及其宿主肿瘤环境细胞中表达升高并且能够影响肿瘤的转移。肿瘤微环境(TME)作为肿瘤赖以生存的环境,在肿瘤的发生及进展过程中发挥着重要的作用。研究表明,DDR2通过与TME中的细胞及非细胞成分相互作用促进肿瘤的生长、增殖、侵袭及转移。全文对DDR2在TME中的作用进行综述,以探讨DDR2作为肿瘤基因治疗这一潜在治疗靶点的应用前景。Discoidin domain receptor 2(DDR2)is a kind of receptor tyrosine kinase(RTK)activated by collagen fibers.In recent years,studies have shown that DDR2 is highly expressed in a variety of tumor cells and tumor environment cells.Tumor microenvironment(TME)plays an important role in tumorigenesis and progression;studies have shown that DDR2 can promote tumor proliferation,invasion and metastasis by interacting with cellular and noncellular components of TME.In this paper,the role of DDR2 in TME is reviewed and the application prospect of DDR2 as a potential therapeutic target for tumor gene therapy is discussed.

关 键 词：盘状结构域受体2 肿瘤微环境 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]