替普瑞酮联合改良四联疗法治疗Hp阳性胃溃疡的效果及对患者心理状态的影响  

Effect of Teprenone Combined with Modified Quadruple Therapy on Hp Positive Gastric Ulcer and its Effect on Psychological State

作　　者：郭秋明 黄二苟 GUO Qiu-ming;HUANG Er-gou(Medical Department of Jishui County Maternal and Child Health Hospital,Jishui 331600,Jiangxi,China;Psychiatric Department of Jishui County People's Hospital,Jishui 331600,Jiangxi,China)

机构地区：[1]吉水县妇幼保健院医务科,江西吉水331600 [2]吉水县人民医院精神科,江西吉水331600

出　　处：《医学信息》2023年第20期153-156,共4页Journal of Medical Information

摘　　要：目的研究替普瑞酮联合改良四联疗法治疗幽门螺杆菌(Hp)阳性胃溃疡的临床效果及对患者心理状态的影响。方法以2019年12月-2020年12月吉水县妇幼保健院收治的60例Hp阳性胃溃疡患者为研究对象,按照随机数字表法分为对照组(30例)与观察组(30例),对照组给予改良四联疗法治疗(泮托拉唑+阿莫西林+克拉霉素+枸橼酸铋钾),观察组则在其基础上加用替普瑞酮治疗,比较两组胃溃疡疗效、Hp根除率、溃疡直径、胃黏膜损伤Lanza评分、心理状态[焦虑自评量表(SAS)、抑郁自评量表(SDS)]、生活质量[消化性溃疡患者生命质量测定量表(QLICD-PU)]。结果观察组胃溃疡治疗有效率高于对照组(P<0.05),但两组Hp根除率比较,差异无统计学意义(P>0.05);两组治疗后溃疡直径、胃黏膜损伤Lanza评分均小于治疗前,且观察组溃疡直径、胃黏膜损伤Lanza评分小于对照组(P<0.05);两组治疗后SAS、SDS评分低于治疗前,且观察组SAS、SDS评分低于对照组(P<0.05);两组治疗后QLICD-PU评分(生理功能、心理功能、社会功能、特异模块)均高于治疗前,且观察组QLICD-PU评分(生理功能、心理功能、社会功能、特异模块)高于对照组(P<0.05)。结论替普瑞酮联合改良四联疗法治疗Hp阳性胃溃疡效果良好,可促进溃疡愈合,减少胃粘膜损伤,改善患者的心理状态及生活质量。Objective To study the clinical effect of teprenone combined with modified quadruple therapy in the treatment of Helicobacter pylori(Hp)positive gastric ulcer and its influence on the psychological state of patients.Methods Sixty patients with Hp-positive gastric ulcer admitted to Jishui County Maternal and Child Health Hospital from December 2019 to December 2020 were enrolled in the study.They were divided into control group(30 patients)and observation group(30 patients)according to the random number table method.The control group was treated with modified quadruple therapy(pantoprazole+amoxicillin+clarithromycin+bismuth potassium citrate),and the observation group was treated with teprenone on the basis of it.The efficacy of gastric ulcer,Hp eradication rate,ulcer diameter,Lanza score of gastric mucosal injury,psychological status[Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS)]and quality of life[Quality of Life Instruments for Chronic Diseases-Peptic Ulcer(QLICD-PU)]were compared between the two groups.Results The effective rate of gastric ulcer treatment in the observation group was higher than that in the control group(P<0.05),but there was no significant difference in the eradication rate of Hp between the two groups(P>0.05).The ulcer diameter and Lanza score of gastric mucosal injury in the two groups after treatment were lower than those before treatment,and the ulcer diameter and Lanza score of gastric mucosal injury in the observation group were lower than those in the control group(P<0.05).The SAS and SDS scores of the two groups after treatment were lower than those before treatment,and the SAS and SDS scores of the observation group were lower than those of the control group(P<0.05).The QLICD-PU scores(physiological function,psychological function,social function,specific module)of the two groups after treatment were higher than those before treatment,and the QLICD-PU scores(physiological function,psychological function,social function,specific module)of the observation group were

关 键 词：幽门螺杆菌 胃溃疡 改良四联疗法 替普瑞酮 

分 类 号：R573.3[医药卫生—消化系统]