伴非自杀性自伤行为的抑郁障碍患者血清炎性标志物水平与冲动特质的相关性  

The correlation between serum inflammatory markers levels and impulsive traits in depression patients with non-suicidal self-injury behavior

作　　者：张爱国 胡晓娟 张许来 Zhang Aiguo;Hu Xiaojuan;Zhang Xulai(Dept of Psychiatry,Affiliated Psychological Hospital of Anhui Medical University,Hefei 230032;Anhui Mental Health Center,Anhui Clinical Research Center for Mental Disorders,Hefei 230022)

机构地区：[1]安徽医科大学附属心理医院精神科,合肥230032 [2]安徽省精神卫生中心,安徽省精神心理疾病临床研究中心,合肥230022

出　　处：《安徽医科大学学报》2023年第10期1769-1772,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省科技厅重点研究与开发计划项目(编号:201904a0702009);安徽省中央引导地方科技发展专项资金(编号:S2020b07030004)。

摘　　要：目的探讨伴非自杀性自伤(NSSI)行为的抑郁障碍患者血清炎性细胞因子水平,并分析炎性细胞因子水平与患者冲动特质的相关性。方法选择40例伴NSSI行为的抑郁障碍患者(NSSI组)、45例不伴NSSI行为的抑郁障碍患者(非NSSI组)、40例正常对照者(正常对照组)入组;采用酶联免疫吸附实验(ELASA)检测被试血清白细胞介素(IL)-2、IL-6、IL-10、IL-15、肿瘤坏死因子(TNF)-α水平;采用汉密尔顿抑郁量表(HAMD)进行病情评估;采用Barratt冲动量表(BIS-11)对患者的冲动性进行评价。结果NSSI组血清IL-2、IL-6、IL-10、IL-15、TNF-α水平较非NSSI组和正常对照组明显升高,差异有统计学意义(P<0.01);NSSI组BIS-11运动因子得分、缺少计划因子得分和总分高于非NSSI组,差异有统计学意义(P<0.01);NSSI组血清IL-2、IL-6、IL-10、IL-15、TNF-α水平与BIS-11运动因子得分、缺少计划因子得分和总分呈正相关(P<0.01)。结论伴NSSI行为的抑郁障碍患者炎性细胞因子水平明显升高,患者具有更明显的冲动性人格特征,炎性细胞因子水平与患者冲动性呈正相关。Objective To explore the difference of serum inflammatory cytokines level in depression patients with non-suicidal self-injury(NSSI),depression patients without NSSI and normal control group,and to analyze the correlation between inflammatory cytokine level and impulsive characteristics of patients in NSSI group.Methods 40 depression patients with NSSI(NSSI group),45 depression patients without NSSI(non-NSSI group)and 40 cases of normal control group were selected,and enzyme-linked immunosorbent assay(ELASA)was used to detect serum IL-2、IL-6、IL-10、IL-15 and TNF-αlevels.The Hamilton Depression Scale(HAMD)was used to evaluate the condition.The patient′s impulsivity was evaluated with Barratt Impulsive-ness Scale(BIS-11).Results The levels of serum IL-2、IL-6、IL-10、IL-15 and TNF-αin the NSSI group were significantly higher than those in the non-NSSI group and the normal control group(P<0.01),and the difference was statistically significant.The score of BIS-11 motor impulsiveness,nonplanning impulsiveness and total score in NSSI group were higher than those in non-NSSI group,with statistically significant difference(P<0.01).The levels of serum IL-2、IL-6、IL-10、IL-15 and TNF-αin NSSI group were positively correlated with BIS-11 motor impulsiveness score,nonplanning impulsiveness score and total score.Conclusion The levels of inflammatory cytokines in depression patients with NSSI increase significantly,and the patients have more obvious impulsive personality characteristics.The levels of inflammatory cytokines is positively correlated with the impulsivity of patients.

关 键 词：抑郁障碍 非自杀性自伤行为 冲动性 炎性细胞因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]