高级别脑膜瘤中异常甲基化调控相关基因识别研究  

Study of genes associated with aberrant methylation regulation in high-grade meningiomas

作　　者：彭怡琛 郑义 李生兰 于建宇 兰燕杰 刘昕蕊 陈峰[1] 李文斌 Peng Yichen;Zheng Yi;Li Shenglan;Yu Jianyu;Lan Yanjie;Liu Xinrui;Chen Feng;Li Wenbin(Department of Neuro-oncology,Cancer Center,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院肿瘤中心神经肿瘤综合治疗病区,北京100070

出　　处：《首都医科大学学报》2023年第5期747-752,共6页Journal of Capital Medical University

基　　金：北京市临床重点专科项目。

摘　　要：目的拟通过生物信息学进一步挖掘高级别脑膜瘤潜在的生物标志物及治疗靶点。方法通过公共数据库大数据分析初步了解高级别脑膜瘤恶性程度高的原因,评估其基因组特性及异常甲基化调控的相关基因。结果识别出表达受异常甲基化调控的基因共3006个,其中突变频率较高的基因210个,挖掘出恶性肿瘤发展、迁移相关通路。结论筛选出高级别脑膜瘤中潜在受异常甲基化调控的基因及相关通路,可作为高级别脑膜瘤的生物标志物及潜在的治疗靶点。Objective To explore potential therapeutic targets with bioinformatics for the treatment of meningiomas,the most common primary central nervous system tumors.Methods A preliminary understanding of the genomic characteristics of high-grade meningiomas was obtained through analysis of public databases to assess the genes associated with aberrant methylation regulation.Results A total of 3006 genes whose expression was regulated by aberrant methylation were identified,including 210 genes with high mutation frequency,and pathways associated with malignant tumor development and migration were mined.Conclusions Genes and related pathways potentially regulated by aberrant methylation in high-grade meningioma provides bio-markers and potential therapeutic targets for high-grade meningioma.

关 键 词：高级别脑膜瘤 异常甲基化 信号通路 

分 类 号：R739.45[医药卫生—肿瘤]