LncRNA-miRNA轴在结直肠癌进展和治疗抗性中的作用  

Role of IncRNA-miRNA axis in colorectal cancer progression and therapy resistance

作　　者：潘莹倩 陈佳祎 张新军[2] 余轩 PAN Yingqian;CHEN Jjiayi;ZHANG Xinjun;YU Xuan(Health Science Center,Ningbo University,Ningbo 315211,China;The First Affiliated Hospital of Ningbo University,Ningbo 315010,China)

机构地区：[1]宁波大学医学部,宁波315211 [2]宁波大学附属第一医院,宁波315010

出　　处：《生命的化学》2023年第9期1356-1363,共8页Chemistry of Life

基　　金：宁波市科技创新2025重大专项项目(2022Z130);2022年浙江省卫生健康科技计划项目(2022KY1150)。

摘　　要：表观遗传因素是生物学和病理机制的关键调节因子,它们可以与不同的分子通路相互作用。长链非编码RNA(long non-coding RNA,lncRNA)作为表观遗传因子通过靶向调控微小RNA(microRNA,miRNA)及相关信号通路,在结直肠癌(colorectal cancer,CRC)中发挥促癌或抑癌作用。因此,根据特定的lncRNA/miRNA相互作用,明确lncRNA-miRNA轴对于CRC的诊断、预后及精准靶向策略具有重要价值。本文就lnc RNA-mi RNA轴在CRC增殖、迁移、侵袭和治疗抗性中的作用及机制进行总结与讨论。Epigenetic factors are key regulators of biological and pathological mechanisms,and they can interact with different molecular pathways.As epigenetic factors,long non-coding RNA(lncRNA)play a role in promoting or suppressing colorectal cancer(CRC)by targeting microRNA(miRNA)and related signaling pathways.Therefore,it is of great value to clarify the lncRNA-miRNA axis according to the specific lncRNA/miRNA interactions for the diagnosis,prognosis and precise targeting strategy of CRC.This article summarizes and discusses the role and mechanism of lncRNA-miRNA axis in the proliferation,metastasis,invasion and therapy resistance of CRC.

关 键 词：长链非编码RNA 微小RNA 结直肠癌 作用机制 化疗耐药性 放疗抗性 

分 类 号：R735.34[医药卫生—肿瘤]