不同类型降糖药物对肺癌的影响  

Effects of different types of antidiabetic drugs on lung cancer

作　　者：杨昱 王侃 丁翠敏[3] 周亚茹[4] Yang Yu;Wang Kan;Ding Cuimin;Zhou Yaru(Department of Pharmacy,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Endoscopy,the Fourth Hospital of Hebei Medical University,Shijiazhuang 0500ll,China;Department of Respiratory Medicine,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Endocrinology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第二医院药学部,石家庄050000 [2]河北医科大学第四医院内镜科,石家庄050011 [3]河北医科大学第四医院呼吸内科,石家庄050011 [4]河北医科大学第三医院内分泌科,石家庄050051

出　　处：《国际呼吸杂志》2023年第9期1100-1103,共4页International Journal of Respiration

基　　金：河北省重点研发计划项目(21377703D)。

摘　　要：肺癌是世界范围内人类癌症相关死亡的最主要原因。糖尿病可因高血糖、高胰岛素血症和炎症等因素导致肿瘤细胞增殖和转移;另外,糖尿病会增加心血管事件、术后并发症和感染的发生风险,进而对肺癌预后产生负面影响。目前常用的降糖药物包括双胍类、α-葡萄糖苷酶抑制剂、胰岛素促泌剂、噻唑烷二酮类、胰岛素、二肽基肽酶4抑制剂、胰高血糖素样肽1受体激动剂、钠-葡萄糖共转运蛋白2抑制剂,各类降糖药物对肺癌的影响仍存在争议,本文就不同种类的降糖药物与肺癌的关系进行综述。Lung cancer is the leading cause of cancer-related deaths in humans worldwide.Diabetes mellitus can lead to tumor cell proliferation and metastasis due to hyperglycemia,hyperinsulinemia and inflammation.Moreover,diabetes mellitus enhance the risks of cardiovascular events,postoperative complications and infections,thus posing negative influences on the prognosis of lung cancer.At present,the commonly used antidiabetic drugs include biguanides,α-glucosidase inhibitors,insulin secretagogues,thiazolidinediones,insulin,dipeptidyl peptidase-4 inhibitors,glucagon-like peptide-1 receptor agonists,and sodium-glucose co-transporter-2 inhibitors.The effects of various types of antidiabetic drugs on lung cancer are still controversial.This article reviews the relationship between different types of antidiabetic drugs and lung cancer.

关 键 词：肺肿瘤 糖尿病 二甲双胍 噻唑烷二酮类 胰岛素 

分 类 号：R734.2[医药卫生—肿瘤] R587.1[医药卫生—临床医学]