上皮性卵巢癌血浆D二聚体、CA125水平对化疗疗效的预测作用  

Predictive effect of plasma D dimer and CA125 levels on chemotherapy efficacy in epithelial ovarian cancer

作　　者：罗涛 肖叙平 童玲[1] 李连业 Luo Tao;Xiao Xuping;Tong Ling;Li Lianye(Taihe County People's Hospital,Ji'an,Jiangxi 343700,China)

机构地区：[1]江西省泰和县人民医院,江西吉安343700

出　　处：《首都食品与医药》2023年第19期79-82,共4页Capital Food Medicine

摘　　要：目的探讨上皮性卵巢癌血浆D二聚体(D-D)、糖类抗原125(CA125)水平对化疗疗效的预测作用。方法选取2020年1月-2022年12月在泰和县人民医院诊治的疑似上皮性卵巢癌患者178例,经病理检查确诊良性92例(良性组),恶性86例(恶性组),另外选取同时期在泰和县人民医院体检健康的女性73名纳入健康对照组,化疗1个疗程结束3周后,根据化疗结果分为化疗有效组(n=60)和化疗无效组(n=26)。对比分析健康对照组、良性组、恶性组血浆D-D、CA125水平;采用Logistic回归分析法分析影响上皮性卵巢癌化疗效果的危险因素。采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析血浆D-D、CA125联合检测对上皮性卵巢癌患者化疗疗效的预测价值。结果恶性组血浆D-D、CA125水平高于良性组、健康对照组(P<0.05),良性组则高于健康对照组(P<0.05)。化疗无效组中年龄≥50岁患者占比、FIGO病理的Ⅲ-Ⅳ期占比、淋巴结有转移占比、有恶性腹腔积液占比、血纤维蛋白原≥4g/L占比及CA125、血浆D-D水平明显高于化疗有效组(P<0.05)。多因素Logistic回归分析显示,FIGO病理Ⅲ-Ⅳ期、淋巴结转移及高表达CA125和血浆D-D均是影响上皮性卵巢癌化疗无效的危险因素(P<0.05)。血浆D-D、CA125及二者联合检测对上皮性卵巢癌患者化疗疗效预测的AUC(95%CI)分别为0.715(0.642-0.773)、0.809(0.756-0.851)、0.887(0.810-0.948),两项指标联合预测效能高于单项检测。结论血浆D-D、CA125在上皮性卵巢癌患者中呈高表达,且是影响患者化疗疗效的危险因素,二者联合检测对化疗疗效有较高的预测价值。Objective To investigate the predictive effect of plasma D dimer and CA125 levels on chemotherapy in epithelial ovarian cancer.Methods 178 patients with suspected epithelial ovarian cancer diagnosed and treated in our hospital from January 2020 to December 2022 were selected.Pathological examination confirmed that 92 cases were benign(benign group)and 86 cases were malignant(malignant group).In addition,73 healthy women who underwent physical examination in our hospital during the same period were selected as healthy control group.3 weeks after the completion of one course of chemotherapy,According to the results of chemotherapy,they were divided into chemotherapy effective group(n=60)and chemotherapy ineffective group(n=26).Plasma D-D,CA125 and combined detection were compared in healthy control group,benign group and malignant group.Logistic regression analysis was used to analyze the risk factors influencing the chemotherapy effect of epithelial ovarian cancer.Receiver operating characteristic curve(ROC)and area under curve(AUC)were used to analyze the predictive value of plasma D-D and CA125 combined detection for chemotherapy efficacy in patients with epithelial ovarian cancer.Results The plasma levels of D-D and CA125 in malignant group were higher than those in benign group and healthy control group(P<0.05),while those in benign group were higher than those in healthy control group(P<0.05).The proportion of patients aged≥50 years old,the proportion of stage Ⅲ to Ⅳ of FIGO pathology,lymph node metastasis,malignant abdominal effusion,the proportion of blood fibringen≥4g/L,CA125 and plasma D-D levels in chemotherapy ineffective group were significantly higher than those in chemotherapy effective group(P<0.05).Multivariate Logistic regression analysis showed that pathological stage Ⅲ to Ⅳ of FIGO,lymph node metastasis,high expression of CA125 and plasma D-D were risk factors for chemotherapy failure of epithelial ovarian cancer(P<0.05).The AUC(95%CI)of plasma D-D,CA125 and combined detection for pr

关 键 词：上皮性卵巢癌 化疗 血浆D二聚体 癌症抗原125 

分 类 号：R737.31[医药卫生—肿瘤]