癌蛋白DEPDC1B的研究进展  

Research progress of oncoprotein DEPDC1B

作　　者：李则明 黄国锦[2] 王晴晴 Ze-Ming LI;Guo-Jin HUANG;Qing-Qing WANG(Medical Department,Wuhan Fourth Hospital,Wuhan 430032,China;Laboratory of Respiratory Diseases,Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Province,China;Department of Ultrasound,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉市第四医院医务处,武汉430032 [2]桂林医学院附属医院呼吸疾病实验室,广西桂林541001 [3]武汉大学中南医院综合超声医学科,武汉430071

出　　处：《医学新知》2023年第5期366-372,共7页New Medicine

基　　金：国家自然科学基金地区科学基金项目(32160156);中央高校基本科研业务费专项资金资助(2042022kf1141)。

摘　　要：含有DEP结构域的蛋白质1B(DEPDC1B)高表达于多种恶性肿瘤组织及细胞,其作为癌蛋白参与了多种癌症的发生发展进程,调控了不同的恶性生物学行为,包括促进肿瘤细胞的侵袭、迁移和增殖以及抑制细胞凋亡等,这与其含有的DEP、Rho GAP等结构域的功能密切相关。本文主要结合癌蛋白DEPDC1B的结构域组成,探讨其与癌症发生发展及治疗的关系,旨在为深入研究DEPDC1B在癌症中的作用机制及潜在的抗癌疗法提供参考依据。DEP domain containing protein 1B(DEPDC1B)is overexpressed in a variety of malignant tissues and cells.As an oncoprotein,it participates in the occurrence and development of many kinds of cancers and regulates different malignant biological forms,including promoting tumor cell invasion,migration,proliferation and inhibiting apoptosis,which is closely related to the function of DEP,Rho GAP and other domains.This paper mainly combines the domain composition of oncoprotein DEPDC1B to explore the relationship between oncoprotein DEPDC1B and the occurrence,development and treatment of cancer,in order to provide a reference basis for further study of the mechanism of DEPDC1B in cancer and potential anticancer therapy.

关 键 词：DEPDC1B DEP结构域 Rho GAP结构域 功能 癌症 

分 类 号：R730[医药卫生—肿瘤]