血清TBIL、CCL18与非小细胞肺癌临床病理特征的相关性  

Correlation between Serum TBIL,CCL18 and Clinicopathologic Features of Non-small Cell Lung Cancer

作　　者：徐道辉 林靓宇 XU Daohui;LIN Liangyu(Pathology Department,Shaowu Municipal Hospital,Shaowu City,Fujian Province 354000;不详)

机构地区：[1]邵武市立医院病理科,福建省邵武市354000 [2]浙江鼎晶医学检验有限公司

出　　处：《医学理论与实践》2023年第20期3430-3432,3439,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨血清胆红素(TBIL)、CC家族趋化因子配体18(CCL18)与非小细胞肺癌(NSCLC)临床病理特征的相关性。方法:将2020年2月—2022年12月我院收治的86例NSCLC患者作为恶性组,选取同期良性肺肿瘤患者86例作为良性组,另选86名健康体检者作为对照组,对比三组受检者TBIL、CCL18表达情况,随后分析86例NSCLC患者临床病理特征与TBIL、CCL18的相关性。结果:恶性组患者CCL18阳性率高于良性组和对照组,TBIL表达水平明显低于良性组和对照组(P<0.05);TBIL、CCL18表达与患者性别、年龄、肿瘤直径无明显相关性,TBIL在TNM分期为Ⅲ~Ⅳ期、有淋巴结浸润、有远处转移、低分化的NSCLC患者中表达水平分别低于TNM分期为Ⅰ~Ⅱ期、无淋巴结浸润、无远处转移、中/高分化的患者(P<0.05);CCL18在TNM分期为Ⅲ~Ⅳ期、有淋巴结浸润、有远处转移的NSCLC患者中阳性表达率分别高于TNM分期为Ⅰ~Ⅱ期、无淋巴结浸润、无远处转移的患者(P<0.05);Spearman相关分析显示,性别、年龄、肿瘤直径和TBIL、CCL18无明显相关性(P>0.05),TNM分期、淋巴结浸润、远处转移与TBIL呈显著负相关,组织分化程度与TBIL呈显著正相关(P<0.05),TNM分期、淋巴结浸润、远处转移与CCL18呈显著正相关(P<0.05)。结论:NSCLC患者中TBIL多呈低水平、CCL18多呈阳性表达,且与患者TNM分期、淋巴结浸润、远处转移、组织分化程度病理特征存在明显相关性。Objective:To investigate the correlation between serum bilirubin(TBIL),CC family chemokine ligand 18(CCL18)and clinicopathologic features of non-small cell lung cancer(NSCLC).Methods:86 patients with NSCLC admitted to our hospital from February 2020 to December 2022 were selected as malignant group.86 patients with benign lung tumor who came to our hospital for treatment during the same period were selected as benign group,and 86 healthy patients who came to our hospital for physical examination during the same period were selected as control group.The expression of TBIL and CCL18 among the three groups were compared.Subsequently,the correlation between clinicopathologic features and TBIL and CCL18 in 86 patients with NSCLC was analyzed.Results:The positive rate of CCL18 in malignant group was higher than that in benign group and control group,and the expression level of TBIL was significantly lower than that in benign group and control group(P<0.05).There was no significant correlation between the expression of TBIL and CCL18 and the gender,age and tumor diameter.The expression level of TBIL in patients with TNM stageⅢ~Ⅳ,lymph node invasion,distant metastasis,and poorly differentiated NSCLC was significantly lower than that in patients with TNM stageⅠ~Ⅱ,no lymph node invasion,no distant metastasis,and medium/highly differentiated patients(P<0.05).The positive expression rate of CCL18 in NSCLC patients with TNM stageⅢ~Ⅳ,lymph node invasion and distant metastasis was significantly higher than that in patients with TNM stageⅠ~Ⅱ,no lymph node invasion and no distant metastasis(P<0.05).Spearman correlation analysis showed that gender,age,tumor diameter were not significantly correlated with CCL18 and TBIL(P>0.05),but TNM stage,lymph node invasion,distant metastasis were significantly negatively correlated with TBIL,tissue differentiation were significanthy postitively correlated with TBIL(P<0.05),TNM stage,lymph node invasion and distant metastasis were significantly positively correlated with CCL18(P

关 键 词：血清胆红素 CC家族趋化因子配体18 非小细胞肺癌 病理特征 

分 类 号：R734.2[医药卫生—肿瘤]