Skeletal contraction:A novel strategy to access multisubstituted cyclobutane  

作　　者：Chunfa Xu V.U.Bhaskara Rao Fen-Er Chen 

机构地区：[1]Institute of Pharmaceutical Science and Technology,College of Chemistry,Fuzhou University,Fuzhou 350108,China [2]Department of Chemical Biology,Max Planck Institute for Molecular Physiology,Dortmund 44227,Germany [3]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai 200433,China [4]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Fudan University,Shanghai 200433,China

出　　处：《Green Synthesis and Catalysis》2022年第1期1-3,共3页绿色合成与催化（英文）

基　　金：C.Xu is grateful to Fuzhou University for the funding support(No.GXRC21051).

摘　　要：The polysubstituted and spirocyclic cyclobutanes were efficiently constructed by the utilization of a novel skeletal contraction strategy which only took one-step synthesis from the readily accessible pyrrolidines.The mechanistic studies indicated that a key intermediate N-aminated pyrrolidine was formed initially and subsequent extrusion of a nitrogen via a radical pathway completed the transformation.This practical methodology was further highlighted by the concise,formal synthesis of the cytotoxic natural product piperarborenine B.

关 键 词：CYCLOBUTANE Skeletal contraction Hypervalent iodine PYRROLIDINES Piperarboreine B 

分 类 号：O62[理学—有机化学]