Visible light-promoted enantioselective aerobic oxidation of pyrazolones by phase transfer catalysis  

作　　者：Yakun Wang Shuaifei Wang Jie Liu Mingming Lian Yifan Chen Ke Wang Yawei Zhang Tao Zhang Lizhen Fang 

机构地区：[1]School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,China [2]Department of Pharmaceutics,Daqing Campus,Harbin Medical University,Daqing 163319,China [3]School of Medical Engineering,Xinxiang Medical University,Xinjiang 453003,China

出　　处：《Green Synthesis and Catalysis》2022年第1期102-109,共8页绿色合成与催化（英文）

基　　金：We would like to thank the University Key Research Projects of Henan Province(No.19A350009);Natural Science Foundation of Henan Province(No.202300410321)for their support.

摘　　要：An efficient and enantioselective aerobic oxidation of 4-substituted pyrazolones has been developed by phase transfer catalysis.Using visible light as the driving force and O_(2)(in air)as the oxidant,broad scopes(38 examples)of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 position were obtained in high yields(up to 98%)and excellent enantioselectivities(up to 93%ee)under mid conditions.The ready availability of catalyst,ease of operation,and low-cost and eco-friendly nature highlighted the practical utility of this visible lightpromoted enantioselective aerobic oxidation.

关 键 词：Aerobic oxidation PYRAZOLONE Visible light Phase transfer catalysis Cinchona alkaloid 

分 类 号：O64[理学—物理化学]