PYRAZOLONE

作品数：42被引量：30H指数：3
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相关领域：理学更多>>
相关机构：大连理工大学更多>>
相关期刊：《Journal of Rare Earths》《Acta Pharmacologica Sinica》《Science China Chemistry》《Chinese Journal of Chemical Engineering》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>
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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking
《Journal of Biosciences and Medicines》2024年第7期214-229,共16页Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão 
Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complica...
关键词：Zika PYRAZOLONE NS5 METHYLTRANSFERASE ANTIVIRALS 
Remote stereocontrol in the(4+2)cycloadditions of 1,7-zwitterions:Asymmetric synthesis of multifunctionalized tetrahydroquinoline derivatives
《Chinese Chemical Letters》2024年第1期222-226,共5页Chen Chen Jin Zhou Jing Jiang Yang Li Ting Mao Cheng Peng Gu Zhan Wei Huang 
the National Natural Science Foundation of China(Nos.82073997 and 22001024);the Science&Technology Department of Sichuan Province(Nos.2021YFS0044 and 2021YJ0402);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202209);Xinglin Scholar Research Promotion Project of Chengdu University of TCM.
The scope of stereochemistry recognition usually occurs near the chiral scaffold of a ligand or catalyst.Remote stereocontrol,which can surpass the limits of stereorecognition of remote prochiral centers,has long been...
关键词：Asymmetric synthesis TETRAHYDROQUINOLINE Remote stereocontrol PYRAZOLONE Lewis base catalysis 1 7-Zwitterion 
Structure-based drug discovery of novel fusedpyrazolone carboxamide derivatives as potent and selective AXL inhibitors
《Acta Pharmaceutica Sinica B》2023年第12期4918-4933,共16页Feifei Fang Yang Dai Hao Wang Yinchun Ji Xuewu Liang Xia Peng Jiyuan Li Yangrong Zhao Chunpu Li Danyi Wangh Yazhou Li Dong Zhang Dan Zhang Meiyu Geng Hong Liu Jing Ai Yu Zhou 
supported by the Natural Science Foundation of China for Innovation Research Group(81821005);the National Natural Science Foundation of China(21977106 and 82173834);the Collaborative Innovation Cluster Project of Shanghai Municipal Commission of Health and Family Planning(2020CXJQ02);the Shanghai Post-doctoral Excellence Program(2022231,China);the Shanghai Sail Program(22YF1460700,China);Lingang Laboratory(LG202103-02-07,China);Lingang Laboratory(LGGG-202204-02,China).
a novel and promising antitumor target,AXL plays an important role in tumor growth,metastasis,immunosuppression and drug resistance of various malignancies,which has attracted extensive research interest in recent yea...
关键词：Potential AXL inhibitor Antitumor activity Structure-based drug design Fused-pyrazolone carboxamide 
Visible light-promoted enantioselective aerobic oxidation of pyrazolones by phase transfer catalysis
《Green Synthesis and Catalysis》2022年第1期102-109,共8页Yakun Wang Shuaifei Wang Jie Liu Mingming Lian Yifan Chen Ke Wang Yawei Zhang Tao Zhang Lizhen Fang 
We would like to thank the University Key Research Projects of Henan Province(No.19A350009);Natural Science Foundation of Henan Province(No.202300410321)for their support.
An efficient and enantioselective aerobic oxidation of 4-substituted pyrazolones has been developed by phase transfer catalysis.Using visible light as the driving force and O_(2)(in air)as the oxidant,broad scopes(38 ...
关键词：Aerobic oxidation PYRAZOLONE Visible light Phase transfer catalysis Cinchona alkaloid 
NHC-catalysed[3+2]-asymmetric annulation between pyrazolin-4,5-diones and enals:synthesis of novel spirocyclic pyrazolone γ-butyrolactones and computational study of mechanism and stereoselectivity
《Organic Chemistry Frontiers》2022年第2期420-427,共8页Marta Gil-Ordonez Alicia Maestro Pablo Ortega Pablo G.Jambrina Jose M.Andres 
Junta de Castilla y León(Projects:FEDER-VA115P17,and VA149G18)for financial support;the Laboratory of Instrumental Techniques(LTI)Research Facilities,Universidad de Valladolid;Junta de Castilla y León for a predoctoral fellowship(EDU/556/2019);grant PID2020-113147GA-I00 funded by MCIN/AEI/10.13039;by the Fundación Salamanca City of Culture and Knowledge(programme for attracting scientific talent to Salamanca);Grant No.EDU/601/2020(Junta de Castilla y Leon and European Social Fund).
Chiral pyrazolones with a spirocyclic centre at the C4-position are widely found in a large family of medically relevant compounds.In recent years,organocatalysis,particularly that performed with quiral N-heterocyclic...
关键词：synthesis spiro mechanism 
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
《Acta Pharmacologica Sinica》2021年第6期964-974,共11页Bo-han Li Mei Zhang Ya-nan Duan Lin Shuai Hao-wen Jiang Jia Li Fa-jun Nan Jing-ya Li 
This work was supported by grants from the National Natural Science Foundation of China(No.81470166 and 81273566);the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(2018ZX09711002).
Beige adipocytes have been considered as a potential strategy in anti-obesity therapy because of its thermogenic capacity.AMP-activated protein kinase(AMPK)plays important roles in regulating adipose tissue function.C...
关键词：AMP-activated protein kinase pyrazolone derivative C29 OBESITY energy expenditure THERMOGENESIS inguinal white adipose tissue white adipose browning 
Novel substituted pyrazolone derivatives as AMP- activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice被引量：2
《Acta Pharmacologica Sinica》2018年第10期1622-1632,共11页Mei ZHANG Zhi-fu XIE Run-tao ZHANG Da-kai CHEN Min GU Shi-chao CUI Yang-ming ZHANG Xin-wen ZHANG Yan-yan YU Jia LI Fa-jun NAN Jing-ya LI 
Non-alcoholic fatty liver disease （NAFLD） is a clinical syndrome characterized by hepatic steatosis. NAFLD is closely linked to obesity, insulin resistance and dyslipidemia. AMp-activated protein kinase （AMPK） fun...
关键词：non-alcoholic fatty liver disease AMP-activated protein kinase AMPK activator homogeneous time-resolved fluorescence metabolic disorders ob/ob mice 
Preparation and photochromic properties of pyrazolones/polyvinyl alcohol composite films
《Chinese Chemical Letters》2017年第2期280-284,共5页Ji-Xi Guo Ming-Xi Guo Dian-Zeng Jia Yin-Hua Li 
supported by the National Natural Science Foundation of China (Nos. 21262038, 21571152 and U1203292);National 973 Program on Key Basic Research Project of China (No. 2014CB660805);the Outstanding Youth Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (No. 201311006)
Novel photochromic composite films have been successfully fabricated by dispersing pyrazolone derivative：1,3-Diphenyl-4-（3-chlorobenzal）-5-hydroxypyrazole 4-phenylsemicarbazone（la） into hydrosol of polyvinyl alco...
关键词：Pyrazolone Polyvinyl alcohol Composite film Photochromism Information storage 
An Eco-Friendly Synthesis of Heterocyclic Moieties Condensed with Pyrazole System under Green Conditions and Their Biological Activity
《Green and Sustainable Chemistry》2016年第2期88-100,共13页Mohamed A. El-Borai Hala F. Rizk Mohamed R. Sadek Mai M. El-Keiy 
The efficient, facile and green synthesis of 4-bromo pyrazolone by using N-bromo saccharine as valuable green reagent encouraged us to prepare some new fused heterocycles as furopyrazole, pyranopyrazole, imidazopyrazo...
关键词：4-Bromo Pyrazolone N-Bromo Saccharine Chitosan Microwave Irradiation DPPH 
Synthesis, Crystal Structure and Biological Properties of One Zinc(Ⅱ) Complex Based on 4-Acyl Pyrazolone Derivative被引量：2
《Chinese Journal of Structural Chemistry》2015年第7期1019-1027,共9页何川川 李玥 赵晶 许贯诚 孙素荣 
Supported by the National Science Foundation of China(No.21161019,21301146);Natural Science Fund for Distinguished Young Scholars of Xinjiang Uygur Autonomous(No.2013711008);Technological Innovation Youth Training Project of Xinjiang Autonomous(No.2013721017)
[Zn（L）（CH3OH）3]（H2L = N-（1-phenyl-3-methyl-4-propenylidene-5-pyrazolone）-salicylidene hydrazide） has been synthesized by the reaction of zinc nitrate and ligand H2 L. The complex crystallizes in orthorhombic s...
关键词：zinc（Ⅱ） complex 4-acyl pyrazolone derivative crystal structure DNA-binding antitumor activity 
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