Protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols  

作　　者：Xuehua Kang Chao Qian He Yang Jicheng Shi Jerome Claverie Wenjun Tang 

机构地区：[1]School of Physical Science and Technology,Shanghai Tech University,Shanghai 200031,China [2]State Key Laboratory of Bio-Organic and Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [3]College of Chemistry,Maoming Technology Center of Organic Materials,Guangdong University of Petrochemical Technology,Maoming 525000,China [4]School of Chemistry and Material Sciences,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [5]Department of Chemistry,University of Sherbrooke,Sherbrooke J1K2R1,Canada

出　　处：《Green Synthesis and Catalysis》2022年第2期185-189,共5页绿色合成与催化（英文）

基　　金：Financial support is provided by the National Natural Science Foundation of China(Nos.82188101,21725205,21432007,21572246,21702223);the Key-Area Research and Development Program of Guangdong Province(No.2020B010188003).

摘　　要：A protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols is realized for the first time with a Pd-WingPhos catalyst,providing expedient access to a series of chiral vinylsubstituted heterocycles in excellent ee and yields under mild reaction conditions.The protocol is applied successfully to the synthesis of a cholesteryl ester transfer protein(CETP)inhibitor.

关 键 词：Tandem allylic substitution WingPhos Protecting-group-free Palladium catalysis ENANTIOSELECTIVITY 

分 类 号：O62[理学—有机化学]