Recent advances using cyclopropanols and cyclobutanols in ring-openingasymmetric synthesis  

作　　者：Hong Yan Gregory S.Smith Fen-Er Chen 

机构地区：[1]Institute of Pharmaceutical Science and Technology,College of Chemistry,Fuzhou University,Fuzhou 350108,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs,Fudan University,Shanghai 200433,China [4]Department of Chemistry,University of Cape Town,Rondebosch,Cape Town 7700,South Africa

出　　处：《Green Synthesis and Catalysis》2022年第3期219-226,共8页绿色合成与催化（英文）

基　　金：Financial support from the Fuzhou University(No.0041/511095)is gratefully acknowledged.We also thank Liuhui Xu for drawing many chemical structures.

摘　　要：Due to high ring strain energies,cyclopropanols and cyclobutanols have a strong tendency of breaking theendocyclic C–C bonds to participate in versatile organic transformations.With an inherent three-dimensionalstructure,cyclopropanols and cyclobutanols have the advantage of synthesizing linear or cyclic molecules withstereogenic centers via ring-opening asymmetric synthesis.There are three strategies for the ring-opening ofcyclopropanols and cyclobutanols usually involved in asymmetric synthesis:1)β-carbon elimination of metalalkoxide;2)radical ring-opening;3)ring-opening via semipinacol rearrangement.The present review has high-lighted the progress developed in the last five years.

关 键 词：Cyclopropanol Cyclobutanol RING-OPENING C–C bond cleavage Asymmetric synthesis 

分 类 号：O62[理学—有机化学]