Carboxylic acid reductases enable intramolecular lactamization reactions  

作　　者：Zongmin Qin Xiaohui Zhang Xianke Sang Wuyuan Zhang Ge Qu Zhoutong Sun 

机构地区：[1]University of Chinese Academy of Sciences,Beijing 100049,China [2]Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China [3]National Technology Innovation Center of Synthetic Biology,Tianjin 300308,China

出　　处：《Green Synthesis and Catalysis》2022年第3期294-297,共4页绿色合成与催化（英文）

基　　金：supported by the National Key Research and Development Program of China(No.2019YFA0905100);the National Natural Science Foundation of China(No.31900909);the Natural Science Foundation Applying a system of Tianjin(No.21JCJQJC00110)and Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-CXRC-009);Mr Qu also thanks financial support from Youth Innovation Promotion Association,CAS(No.2021175).

摘　　要：As a versatile type of enzyme,carboxylic acid reductases(CAR)can not only reduce various carboxylic acids to aldehydes in cooperation with cofactors ATP and NADPH but also catalyze the synthesis of amides and esters in the absence of NADPH.Here,we report an intramolecular cyclization catalyzed by CAR only with the use of ATP to transform amino acids into diverse lactams,includingγ-/δ-/ε-lactams and chiral derivatives thereof.The observed wide substrate scope and selectivity enable potential applications to be implemented.Our results demonstrate that CAR-catalyzed lactamization is a promising approach for the synthesis of chiral lactam com-pounds under mild conditions,thereby enriching the toolbox for the biosynthesis of lactams as a viable alternative to purely chemical procedures.

关 键 词：BIOCATALYSIS LACTAMS Carboxylic acid reductase Intramolecular cyclization Lactamization 

分 类 号：O62[理学—有机化学]