右美托咪定预防颅脑外伤患者发生阵发性交感神经过度兴奋综合征的价值  

The Value of Dexmedetomidine in Preventing Paroxysmal Sympathetic Hyperexcitability Syndrome in Patients with Craniocerebral Trauma

作　　者：李佳霖[1] 来永光 张建斌[1] Li Jialin;Lai Yongguang;Zhang Jianbin(Department of Neurosurgery,Shandong Pingdu People's Hospital,Qingdao 266700,Shandong Province,China)

机构地区：[1]山东省平度市人民医院神经外科,山东青岛266700

出　　处：《中外医药研究》2023年第15期42-44,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：青岛市卫生科技计划项目(编号:2020-WJZD259)。

摘　　要：目的:探讨右美托咪定对预防颅脑外伤患者发生阵发性交感神经过度兴奋(PSH)综合征的价值。方法:选取2019年1月—2022年12月山东省平度市人民医院收治的颅脑外伤患者84例作为研究对象,根据随机数字表法分为右美托咪定组和生理盐水组,各42例。患者均采用手术治疗,生理盐水组在麻醉诱导前注射生理盐水,右美托咪定组在麻醉诱导前给予右美托咪定。比较两组患者PSH综合征发生率、总住院时间、机械通气时间、ICU住院时长、血清炎性因子水平。结果:治疗后7d和3个月,右美托咪定组患者PSH综合征发生率均低于生理盐水组,差异有统计学意义(P<0.05);右美托咪定组患者总住院时间、ICU住院时长、机械通气时间均短于生理盐水组,差异有统计学意义(P<0.001);术后24 h,两组患者肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平均升高,右美托咪定组患者TNF-α、IL-6水平均低于生理盐水组,差异有统计学意义(P<0.05)。结论:右美托咪定能够有效降低颅脑外伤患者术后PSH发生率,降低患者血清炎性因子水平,促进患者术后恢复。Objective:To explore the value of dexmedetomidine in preventing the occurrence of paroxysmal sympathetic hyperexcitability(PSH)syndrome in patients with craniocerebral trauma.Methods:Eighty-four patients with craniocerebral trauma admitted to Shandong Pingdu People's Hospital from January 2019 to December 2022 were selected as the study subjects,and they were divided into the dexmedetomidine group and the saline group according to the method of randomized numerical table,each with forty-two cases.The patients were treated with surgery,saline group was injected with saline before anesthesia induction,and dexmedetomidine group was given dexmedetomidine before anesthesia induction.The incidence of PSH syndrome,total hospitalization time,mechanical ventilation time,length of ICU hospitalization,and serum inflammatory factor levels were compared between the two groups.Results:The incidence of PSH syndrome in patients in the dexmedetomidine group was lower than that in the saline group at 7 d and 3 months after treatment,and the difference was statistically significant(P<0.05);The total hospitalization time,ICU length of stay,and mechanical ventilation time of patients in the dexmedetomidine group were shorter than those in the saline group,and the difference was statistically significant(P<0.001);At 24 h after surgery,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were elevated in both groups,and the levels of TNF-αand IL-6 in patients in the dexmedetomidine group were lower than those in the saline group,with statistically significant differences(P<0.05).Conclusion:Dexmedetomidine can effectively reduce the incidence of postoperative PSH in patients with craniocerebral trauma,lower the level of serum inflammatory factors in patients,and promote patients'postoperative recovery.

关 键 词：右美托咪定 颅脑外伤 阵发性交感神经过度兴奋综合征 

分 类 号：R73[医药卫生—肿瘤]