多发性骨髓瘤致癌蛋白1与多配体蛋白聚糖-1在反复移植失败患者子宫内膜中的表达情况及其临床意义  

Expression of Multiple Myeloma Oncoprotein 1 and Multiligand Proteoglycan 1 in the Endometrium of Patients with Repeated Transplantation Failure and Its Clinical Significance

作　　者：曾鸿[1] 徐见兴[2] 李胜远 果海娜 Zeng Hong;Xu Jianxing;Li Shengyuan;Guo Haina(Department of Pathology,Dongguan Maternal and Child Health Hospital,Dongguan 523000,Guangdong Province,China;Department of Obstetrics and Gynecology,Dongguan Maternal and Child Health Hospital,Dongguan 523000,Guangdong,China)

机构地区：[1]东莞市妇幼保健院病理科,广东东莞523000 [2]东莞市妇幼保健院妇产科,广东东莞523000

出　　处：《中外医药研究》2023年第15期131-133,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：东莞市科技局立项(编号:202050715007858)。

摘　　要：目的:研究多发性骨髓瘤致癌蛋白1(MUM1)与多配体蛋白聚糖-1(CD138)在反复移植失败(RIF)患者子宫内膜中的表达情况及其临床意义。方法:选取2019年4月—2021年10月就诊于东莞市妇幼保健院生殖医学中心的RIF患者70例作为研究对象,对其子宫内膜组织分别进行HE染色、CD138免疫组化单染及MUM1/CD138免疫组化双染。比较阳性率、MUM1/CD138双染阳性患者临床抗生素治疗情况;比较治疗组与未治疗组临床妊娠率。结果:MUM1/CD138双染阳性率、CD138单染阳性率与HE染色阳性率比较,差异有统计学意义(P<0.05);MUM1/CD138双染阳性率与CD138单染阳性率比较,差异无统计学意义(P>0.05);MUM1/CD138双染阳性患者治疗前、后的临床妊娠率比较,差异有统计学意义(P=0.044);治疗组临床妊娠率高于未治疗组,差异有统计学意义(P<0.05)。结论:RIF患者子宫内膜可见≥1个MUM1/CD138免疫组化双染阳性的浆细胞,临床抗生素治疗后能有效提高患者的临床妊娠率,改善其妊娠结局。Objective:To study the expression of multiple myeloma oncoprotein 1(MUM1)and leukocyte differentiation antigen 138(CD138)in the endometrium of patients with recurrent transplantation failure(RIF)and their clinical significance.Methods:Seventy RIF patients who attended the Reproductive Medicine Center of Dongguan Maternal and Child Health Hospital from April 2019 to October 2021 were selected as the study subjects,and their endometrial tissues were stained with HE staining,single staining with CD138 immunohistochemistry,and double staining with MUM1/CD138 immunohistochemistry,respectively.The positive rate,clinical antibiotic treatment of patients with positive MUM1/CD138 double staining were compared,and the clinical pregnancy rate of the treated group was compared with that of the untreated group.Results:The positive rate of MUM1/CD138 double staining,the positive rate of CD138 single staining and the positive rate of HE staining were compared,and the difference was statistically significant(P<0.05);The difference was not statistically significant when comparing the positive rate of MUM1/CD138 double staining with the positive rate of CD138 single staining(P>0.05);Comparison of the clinical pregnancy rates of MUM1/CD138 double staining positive patients before and after treatment,the difference was statistically significant(P=0.044);The clinical pregnancy rate in the treated group was higher than that in the untreated group,and the difference was statistically significant(P<0.05).Conclusion:≥1 MUM1/CD138 immunohistochemistry double staining positive plasma cells were seen in the endometrium of patients with RIF,and clinical antibiotic treatment was effective in increasing the clinical pregnancy rate and improving the pregnancy outcome of the patients.

关 键 词：反复种植失败 慢性子宫内膜炎 免疫组化双染 CD138 MUM1 

分 类 号：R73[医药卫生—肿瘤]