脊髓室管膜区内源性神经干细胞在脊髓损伤修复中的潜在作用机制研究  

The Potential Role of Endogenous Neural Stem Cells in Ependymal Region of Spinal Cord in the Repair of Spinal Cord Injury

作　　者：仲文庆 俞兴[1] 杨永栋[1] ZHONG Wen-qing;YU Xing;YANG Yong-dong(Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《神经损伤与功能重建》2023年第10期589-592,共4页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金(No.81973882)。

摘　　要：脊髓损伤是中枢神经系统的严重损伤,目前尚缺乏有效的治疗。近年来发现脊髓室管膜区存在内源性神经干细胞(ENSCs)具有促进脊髓损伤修复的潜力。脊髓损伤及微环境改变等可使脊髓室管膜区的ENSCs激活、增殖、分化,进一步修复受损的神经结构。虽然脊髓室管膜区ENSCs在脊髓损伤修复中具有积极作用,但其机制尚无定论。本文对脊髓室管膜区ENSCs在脊髓损伤修复中潜在作用机制进行综述,为基础和临床领域全面认识脊髓室管膜区ENSCs提供参考。Spinal cord injury is a serious injury of the central nervous system,and there is currently a lack of effective treatment.In recent years,it has been found that endogenous neural stem cells(ENSCs)in ependymal region of spinal cord have the potential to promote the repair of spinal cord injury.Spinal cord injury and microenvironment changes can promote the activation,proliferation,and differentiation of ENSCs in the ependymal region of the spinal cord,which helps to repair damaged neural structures.Although ENSCs play a positive role in the repair of spinal cord injury,the mechanism remains inconclusive.This article reviews the potential mechanism of spinal cord ependymal region ENSCs in the repair of spinal cord injury,providing more data to know the function of ENSCs in ependymal region of spinal cord from both basic and clinical perspective.

关 键 词：脊髓损伤 内源性神经干细胞 室管膜细胞 增殖 分化 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R744