复元醒脑汤治疗急性脑梗死的Meta分析  

Meta-analysis of Fuyuan Xingnao Decoction in the Treatment of Aacute Cerebral Infarction

作　　者：霍晨星 徐湘茹 吴霖光缙 杨红强 方邦江[1] Huo Chenxing;Xu Xiangru;Wu Linguangjin;Yang Hongqiang;Fang Bangjiang(Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学,上海201203

出　　处：《中国中医急症》2023年第10期1701-1706,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(8197151748);上海市临床重点专科(shslczdzk04401);华东片区及市级中医专科专病联盟建设(ZY[2021-2023]-0302)。

摘　　要：目的系统评价复元醒脑汤治疗急性脑梗死的有效性和安全性,为复元醒脑汤治疗急性脑梗死提供循证医学证据。方法通过检索中国知网(CNKI)、中文科技期刊数据库(VIP)、万方数据知识服务平台、中国生物医学文献服务系统(CBM)、PubMed、Embase、Cochrane Library(Cochrane图书馆)进行文献筛选。采用Cochrane协作网研发的偏倚风险评估工具进行研究质量的评价。采用Stata 15.0软件进行Meta分析、敏感性分析和发表偏倚分析。结果共纳入符合要求的中文文献17篇,共1617例患者。Meta分析结果表明:复元醒脑汤联合西医常规治疗的总有效率[相对危险度(RR)=1.23,95%置信区间(95%CI)(1.16,1.31),P<0.05]、美国国立卫生院卒中量表(NIHSS)评分[加权均数差(WMD)=3.91,95%CI(2.55,5.27),P<0.05]、Barthel指数(BI)量表评分[WMD=-10.90,95%CI(-16.14,-5.66),P<0.05]均优于对照组,差异均有统计学意义。不良反应发生率[RR=0.46,95%CI(0.12,1.69),P>0.05],差异无统计学意义。结论复元醒脑汤联合西医常规治疗与单用西医常规治疗相比可有效提高脑梗死总有效率、降低NIHSS评分,提高BI评分,但其安全性有待更多证据支持。以上结论存在相关文献质量与数量的限制,仍有待更多高质量的随机对照试验完善。Objective:To systematically evaluate the efficacy and safety of Fuyuan Xingnao Decoction in the treatment of acute cerebral infarction and to provide evidence-based medical evidence for Fuyuan Xingnao Decoctionin the treatment of acute cerebral infarction.Methods:Literature screening was conducted by searching CNKI,VIP,Wanfang Data Knowledge Service Platform,China Biomedical Literature Service System(CBM),PubMed,Embase,Cochrane Library.The bias risk assessment tool developed by Cochrane collaboration network was used to evaluate the research quality.Meta-analysis,sensitivity analysis and publication bias analysis were carried out using Stata 15.0 software.Results:A total of 1617 patients were included in 17 qualified Chinese literatures.The results of meta-analysis showed that the total effective rate of Fuyuan Xingnao Decoction combined with conventional western medicine treatment[relative risk(RR)=1.23,95%confidence interval(95%CI)(1.16,1.31),P<0.05],NIHSS score[WMD=3.91,95%CI(2.55,5.27),P<0.05],BI scale score[WMD=-10.90,95%CI(-16.14,-5.66),P<0.05]were better than the control group,and the differences were statistically significant.The incidence of adverse reactions[RR=0.46,95%CI(0.12,1.69),P>0.05]showed no statistically significant difference.Conclusion:Fuyuan Xingnao Decoction combined with conventional western medicine can effectively improve the total effective rate of cerebral infarction,reduce the NIHSS score and improve the BI score.The above conclusions are limited by the quality and quantity of relevant literature and need to be improved by more high-quality randomized controlled trials.

关 键 词：急性脑梗死 复元醒脑汤 META分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]