Non-alcoholic fatty liver disease:Dietary and nutraceutical approaches  

作　　者：Ludovica Cogorno Elena Formisano Andrea Vignati Amalia Prigione Antonio Tramacere Consuelo Borgarelli Samir Giuseppe Sukkar Livia Pisciotta 

机构地区：[1]Department of Experimental Medicine-Medical Pathophysiology,Food Science and Endocrinology Section,Sapienza University of Rome,Rome,Italy [2]Department of Internal Medicine,University of Genoa,Genoa,Italy [3]Dietetics and Clinical Nutrition Unit,IRCCS Policlinic Hospital San Martino,Genoa,Italy

出　　处：《Liver Research》2023年第3期216-227,共12页肝脏研究（英文）

摘　　要：Non-alcoholic fatty liver disease(NAFLD),defined as the presence of fat accumulation in imaging or histology in more than 5%of hepatocytes and exclusion of other causes for secondary hepatic fat accumulation,is one of the major causes of chronic liver disease worldwide.Metabolic syndrome is associated with an increased risk of progression from NAFLD to non-alcoholic steatohepatitis(NASH),fibrosis,and forthcoming liver failure.Also,genetic predisposition contributes to the risk of NAFLD development.This review explores the role of diets and nutraceuticals in delaying the development and the evolution of NAFLD to chronic liver disease.The Mediterranean diet,high-protein diet,lowcarbohydrate/high-fat diet,high-carbohydrate/low-fat diet,and intermittent fasting are the dietary approaches investigated given the presence of relevant literature data.Moreover,this review focused on nutraceuticals with proven efficacy in ameliorating NAFLD and grouped them into four different categories:plant-based nutraceuticals(Ascophyllum nodosum and Fucus vesiculosus,Silymarin,Berberine,Curcumin,Resveratrol,Nigella sativa,Quercetin),vitamin-like substances(vitamin E,vitamin D,vitamin C,coenzyme Q10,inositol),fatty acids(omega-3),and microbiota-management tools(probiotics).

关 键 词：Non-alcoholic fatty liver disease(NAFLD) Metabolic-associated fatty liver disease(MAFLD) Non-alcoholic steatohepatitis(NASH) Non-alcoholic fatty liver(NAFL) DIETS NUTRACEUTICALS 

分 类 号：R575.5[医药卫生—消化系统]