氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中的临床疗效  

Clinical efficacy of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke

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作  者:郝丕达 HAO Pida(Department of Neurology,the Third People's Hospital of Linyi,Linyi,Shandong,276023,China)

机构地区:[1]临沂市第三人民医院神经内科,山东临沂276023

出  处:《当代医学》2023年第23期73-76,共4页Contemporary Medicine

摘  要:目的探讨氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中的临床疗效。方法选取2020年7月至2021年7月本院收治的72例进展性缺血性脑卒中患者作为研究对象,随机分为对照组与观察组,每组36例。对照组采用低分子肝素钙治疗,观察组采用氯吡格雷联合低分子肝素钙治疗,比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)、社会支持度量表(SSRS)、血流动力学指标及生命质量。结果观察组治疗总有效率(97.22%)高于对照组(80.56%),差异有统计学意义(P<0.05)。干预后,两组NIHSS均低于干预前,SSRS均高于干预前,且观察组NIHSS低于对照组,SSRS高于对照组,差异有统计学意义(P<0.05)。干预后,两组血浆黏度、纤维蛋白原、血小板聚集率均低于干预前,且观察组低于对照组,差异有统计学意义(P<0.05)。干预后,两组躯体功能、情绪状态、社交状态、健康认知评分均高于干预前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中疗效显著,能改善患者神经功能和血流动力学水平,提高生命质量,值得临床推广应用。Objective To explore the clinical efficacy of clopidogrel combined with low molecular weight heparin calcium in the treatment of progressive ischemic stroke.Methods 72 patients with progressive ischemic stroke admitted to our hospital from July 2020 to July 2021 were selected as the research subjects,and they were divided into the control group and the observation group,with 36 cases in each group.The control group was treated with low molecular weight heparin calcium,and the observation group was treated with clopidogrel combined with low molecular weight heparin calcium.The clinical efficacy,National Institute of Health stroke scale(NIHSS),social support revalued scale(SSRS),hemodynamic indexes and quality of life were compared between the two groups.Results The total effective rate in the observation group(97.22%)was higher than that in the control group(80.56%),and the difference was statistically significant(P<0.05).After the intervention,the NIHSS of the two groups was lower than that before the intervention,and the SSRS was higher than that before the intervention,and the NIHSS in the observation group was lower than that in the control group,and the SSRS was higher than that in the control group,and the difference was statistically significant(P<0.05).After the intervention,the plasma viscosity,fibrinogen and platelet aggregation rate of the two groups were lower than those before the intervention,and the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the intervention,the scores of physical function,emotional state,social state and health cognition of the two groups were higher than those before the intervention,and the observation group was higher than in the control group,and the differences were statistically significant(P<0.05).Conclusion Clopidogrel combined with low molecular weight heparin calcium is effective in the treatment of progressive ischemic stroke,which can improve the neurological function and hemodynamic level

关 键 词:氯吡格雷 低分子肝素钙 进展性缺血性脑卒中 

分 类 号:R743.3[医药卫生—神经病学与精神病学]

 

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