肿瘤内细菌的特征及其与肿瘤治疗的关联和影响  

Characteristics of intratumoral bacteria and their effects on tumor treatment

作　　者：林淦 黄嘉元 何裕隆 张华[2] 牟相宇[1] Lin Gan;Huang Jiayuan;He Yulong;Zhang Hua;Mou Xiangyu(Cancer for Infection and Immunity Studies,School of Medicine,Sun Yat-Sen University,Shenzhen 518107,Guangdong,China;Department of Digestive Medicine,The Seventh Affiliated Hospital of Sun Yat-Sen University,Shenzhen 518107,Guangdong,China)

机构地区：[1]中山大学医学院感染免疫中心,广东深圳518107 [2]中山大学附属第七医院消化医学中心,广东深圳518107

出　　处：《消化肿瘤杂志（电子版）》2023年第3期257-261,共5页Journal of Digestive Oncology(Electronic Version)

摘　　要：恶性肿瘤是当今医学界面临的一项重大挑战,是影响人类生命健康的重要因素。肠道菌群对肿瘤的发生、发展和药物疗效具有一定影响。随着基因测序技术和生物信息学的发展,研究者们相继在多种肿瘤中发现了细菌。常见的瘤内细菌有梭杆菌(Fusobacterium)、拟杆菌(Bacteroides)、普雷沃氏菌(Prevotella)等。作为肿瘤微环境中的组成部分,瘤内细菌可能对于肿瘤的增殖、转移以及耐药性产生影响,潜在的机制包括激活致癌通路、调节免疫反应、代谢药物等。本文针对瘤内细菌的新近研究展开综述,总结瘤内细菌特征与组成,探讨瘤内细菌与肿瘤的关联和作用,并为开发新的肿瘤治疗手段提供参考。Malignant tumor is a serious medical challenge and an important factor affecting the health of humans.Tumor occurrence,development and drug efficacy are influenced by gut microbiota.Researchers have detected bacteria in various tumor consecutively.Common intratumoral bacteria genera include Fusobacterium,Bacteroides and Prevotella.As a composition of tumor microenvironment,intratumoral bacteria may influence tumor proliferation,metastasis and drug resistance.The potential mechanisms include activation of carcinogenic pathway,regulation of immune response,and drug metabolism.In this review,latest studies of intratumoral bacteria are summarized,including the characteristics and composition of intratumoral bacteria,and the association between intratumoral bacteria and tumors.This review provides a reference for the development of novel anti-cancer treatments targeting intratumoral bacteria.

关 键 词：瘤内细菌 肿瘤 肿瘤微环境 

分 类 号：R730.5[医药卫生—肿瘤]