Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection,quantification and grading of hepatic steatosis  

作　　者：Mohamed Elfaal Alanna Supersad Craig Ferguson Stephanie Locas Florin Manolea Mitchell P Wilson Medica Sam Wendy Tu Gavin Low 

机构地区：[1]Department of Radiology&Diagnostic Imaging,University of Alberta,Edmonton T6G2B7,Alberta,Canada

出　　处：《World Journal of Radiology》2023年第10期293-303,共11页世界放射学杂志（英文版）（电子版）

摘　　要：BACKGROUND Hepatic steatosis is a very common problem worldwide.AIM To assess the performance of two-and six-point Dixon magnetic resonance(MR)techniques in the detection,quantification and grading of hepatic steatosis.METHODS A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease.MR sequences included two-point Dixon,six-point Dixon,MR spectroscopy(MRS)and MR elastography.Fat fraction(FF)estimates on the Dixon techniques were compared to the MRS-proton density FF(PDFF).Statistical tests used included Pearson’s correlation and receiver operating characteristic.RESULTS FF estimates on the Dixon techniques showed excellent correlation(≥0.95)with MRS-PDFF,and excellent accuracy[area under the receiver operating characteristic(AUROC)≥0.95]in:(1)Detecting steatosis;and(2)Grading severe steatosis,(P<0.001).In iron overload,two-point Dixon was not evaluable due to confounding T2*effects.FF estimates on six-point Dixon vs MRS-PDFF showed a moderate correlation(0.82)in iron overload vs an excellent correlation(0.97)without iron overload,(P<0.03).The accuracy of six-point Dixon in grading mild steatosis improved(AUROC:0.59 to 0.99)when iron overload cases were excluded.The excellent correlation(>0.9)between the Dixon techniques vs MRSPDFF did not change in the presence of liver fibrosis(P<0.01).CONCLUSION Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.

关 键 词：Chemical shift encoded Dixon magnetic resonance techniques Hepatic steatosis Liver fat quantification Magnetic resonance spectroscopy Proton density fat fraction ULTRASOUND 

分 类 号：R734.5[医药卫生—肿瘤] R445.2[医药卫生—临床医学]