Novel prognostic score based on the preoperative total bilirubinalbumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma  

作　　者：Xiao-Jie Zhang He Fei Chong-Yuan Sun Ze-Feng Li Zheng Li Chun-Guang Guo Dong-Bing Zhao 

机构地区：[1]Department of Pancreatic and Gastric Surgical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第10期2247-2258,共12页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND The preoperative total bilirubin-albumin ratio(TBAR)and fibrinogen-albumin ratio(FAR)have been proven to be valuable prognostic factors in various cancers.AIM To detect the prognostic value of TBAR and FAR in ampullary adenocarcinoma(AC)patients who underwent curative pancreaticoduodenectomy.METHODS AC patients who underwent curative pancreaticoduodenectomy in the National Cancer Center of China between 1998 and 2020 were retrospectively reviewed.The prognostic cutoff values of TBAR and FAR were determined through the best survival separation model.Then,a novel prognostic score combining TBAR and FAR was calculated and validated through the logistic regression analysis and Cox regression analysis.RESULTS A total of 188 AC patients were enrolled in the current study.The best cutoff values of TBAR and FAR for predicting overall survival were 1.7943 and 0.1329,respectively.AC patients were divided into a TBAR-low group(score=0)vs a TBAR-high group(score=1)and a FAR-low group(score=0)vs a FAR-high group(score=1).The total score was calculated as a novel prognostic factor.Multivariable logistic regression analysis revealed that a high score was an independent protective factor for recurrence[score=1 vs score=0:Odds ratio(OR)=0.517,P=0.046;score=2 vs score=0 OR=0.236,P=0.038].In addition,multivariable survival analysis also demonstrated that a high score was an independent protective factor in AC patients(score=2 vs score=0:Hazard ratio=0.230,P=0.046).CONCLUSION A novel prognostic score based on preoperative TBAR and FAR has been demonstrated to have good predictive power in AC patients who underwent curative pancreaticoduodenectomy.However,more studies with larger samples are needed to validate this conclusion.

关 键 词：Ampullary adenocarcinoma Total bilirubin-albumin ratio Fibrinogen-albumin ratio Recurrence Overall survival 

分 类 号：R735.2[医药卫生—肿瘤]