Partners in diabetes epidemic:A global perspective  

作　　者：Huan Wang Safoura Akbari-Alavijeh Ranjit S Parhar Randy Gaugler Sarwar Hashmi 

机构地区：[1]College of Bioscience and Biotechnology,Shenyang Agricultural University,Shenyang 110866,Liaoning Province,China [2]Rutgers Center for Vector Biology,Rutgers University,New Brunswick,NJ 08901,United States [3]Department of Food Science and Technology,College of Agriculture,Isfahan University of Technology,Isfahan 84156-83111,Iran [4]Department of Biological and Medical Research,King Faisal Specialist Hospital and Research Centre,Riyadh 11211,Saudi Arabia [5]Research and Diagnostics,Ghazala and Sanya Hashmi Foundation,Holmdel,NJ 07733,United States

出　　处：《World Journal of Diabetes》2023年第10期1463-1477,共15页世界糖尿病杂志（英文版）（电子版）

摘　　要：There is a recent increase in the worldwide prevalence of both obesity and diabetes.In this review we assessed insulin signaling,genetics,environment,lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes diseases.We searched relevant articles,which have key information from laboratory experiments,epidemiological evidence,clinical trials,experimental models,metaanalysis and review articles,in PubMed,MEDLINE,EMBASE,Google scholars and Cochrane Controlled Trial Database.We selected 144 full-length articles that met our inclusion and exclusion criteria for complete assessment.We have briefly discussed these associations,challenges,and the need for further research to manage and treat diabetes more efficiently.Diabetes involves the complex network of physiological dysfunction that can be attributed to insulin signaling,genetics,environment,obesity,mitochondria and stress.In recent years,there are intriguing findings regarding gut microbiome as the important regulator of diabetes.Valid approaches are necessary for speeding medical advances but we should find a solution sooner given the burden of the metabolic disorder―What we need is a collaborative venture that may involve laboratories both in academia and industries for the scientific progress and its application for the diabetes control.

关 键 词：DIABETES Diabetes mellitus ENDOCRINOLOGY Genes Gut microbiota Environment Insulin signaling Metabolic disorder MITOCHONDRIA Obesity 

分 类 号：R587.1[医药卫生—内分泌] R749.1[医药卫生—内科学]