替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床效果及安全性研究  

Study on clinical effect and safety of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis

作　　者：王慧颖[1] WANG Hui-ying(Department of Pharmacy,Shenyang Stomatological Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市口腔医院药剂科,110000

出　　处：《中国现代药物应用》2023年第19期124-126,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎(CP)的临床效果及安全性。方法 100例CP患者,随机分为观察组与对照组,各50例。对照组给予替硝唑片治疗,观察组在对照组基础上加用盐酸米诺环素软膏治疗。比较两组龈沟液白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)水平及外周血辅助性T细胞17(Th17)、调节性T细胞(Treg)占CD4^(+)T细胞的比例,药物不良反应发生率。结果 治疗后,观察组龈沟液IL-10、TGF-β水平分别为(19.72±3.49)ng/ml、(72.47±14.06)μg/ml,均高于对照组的(15.85±2.96)ng/ml、(59.52±11.24)μg/ml,外周血Th17占CD4^(+)的百分比、Treg占CD4^(+)T细胞的比例分别为(1.38±0.26)%、(4.25±0.74)%,明显低于对照组的(1.72±0.35)%、(4.87±0.85)%,差异有统计学意义(P<0.05)。观察组药物不良反应发生率为14.0%,与对照组的12.0%比较,差异无统计学意义(P>0.05)。结论 替硝唑片联合盐酸米诺环素软膏治疗CP疗效显著,可以提高患者龈沟液的IL-10和TGF-β水平,降低外周血的Th17、Treg的比例,且不增加药物不良反应发生率,值得进行临床推广。Objective To analyze the clinical effect and safety of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis(CP).Methods A total of 100 CP patients were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with tinidazole tablets,and the observation group was treated with minocycline hydrochloride ointment on the basis of the control group.Both groups were compared in terms of levels of interleukin-10(IL-10),transforming growth factor-β(TGF-β)in gingival crevicular fluid,percentages of peripheral blood T-helper 17+(Th17)and regulatory T(Treg)cells in CD4^(+) T cells,and the incidence of adverse drug reactions.Results After treatment,the levels of IL-10 and TGF-βin the observation group were(19.72±3.49)ng/ml and(72.47±14.06)μg/ml,which were higher than those of(15.85±2.96)ng/ml and(59.52±11.24)μg/ml in the control group;+the percentages of peripheral blood Th17 and Treg in CD4^(+) T cells in the observation group were(1.38±0.26)%and(4.25±0.74)%,which were significantly lower than those of(1.72±0.35)%and(4.87±0.85)%in the control group,and the difference were statistically significant(P<0.05).The incidence of adverse drug reactions in the observation group was 14.0%,and the difference was not statistically significant from that of 12.0%in the control group(P>0.05).Conclusion Tinidazole combined with minocycline hydrochloride ointment is effective in the treatment of CP.It can increase the level of IL-10 and TGF-βin gingival crevicular fluid and decrease the level of TH17 and Treg in peripheral blood,and does not increase the incidence of adverse drug reactions,which is worthy of clinical promotion.

关 键 词：慢性牙周炎 替硝唑片 盐酸米诺环素软膏 安全性 

分 类 号：R781.4[医药卫生—口腔医学]