阿立哌唑联合舍曲林治疗强迫症患者的疗效观察  

Efficacy observation of aripiprazole combined with sertraline in the treatment of patients with obsessive-compulsive disorder

作　　者：姜洪伟 JIANG Hong-wei(Linyi Central Hospital,Linyi 276400,China)

机构地区：[1]临沂市中心医院,276400

出　　处：《中国现代药物应用》2023年第19期127-129,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析阿立哌唑联合舍曲林治疗强迫症的临床疗效。方法 94例强迫症患者,随机分为单一组和治疗组,每组47例。单一组给予舍曲林治疗,治疗组在单一组基础上增加阿立哌唑治疗。比较两组患者临床疗效,汉密尔顿焦虑量表(HAMA)、耶鲁-布朗强迫量表(YBOCS)评分,肿瘤坏死因子-α(TNF-α)、脑源性神经营养因子(BDNF)水平。结果 治疗前,两组HAMA及YBOCS评分比较,差异无统计学意义(P>0.05);治疗后,治疗组HAMA评分(8.13±1.79)分、YBOCS评分(9.91±2.05)分均低于单一组的(11.85±2.46)、(13.75±3.68)分,差异有统计学意义(P<0.05)。治疗前,两组TNF-α、BDNF水平比较,差异无统计学意义(P>0.05);治疗后,治疗组TNF-α(39.17±4.05)μg/L、BDNF(39.78±4.22)μg/L均高于单一组的(33.82±4.62)、(31.06±4.85)μg/L,差异有统计学意义(P<0.05)。治疗组治疗总有效率95.74%高于单一组的76.60%,差异有统计学意义(P<0.05)。结论 强迫症患者采用阿立哌唑联合舍曲林的疗效确切,能有效减轻神经损伤情况,纠正患者强迫思维和行为,加速强迫症的恢复,该方案可推广。Objective To analyze the clinical efficacy of aripiprazole combined with sertraline in the treatment of patients with obsessive-compulsive disorder.Methods A total of 94 patients with obsessive-compulsive disorder were randomly divided into single group and treatment group,with 47 cases in each group.The single group was treated with sertraline,and the treatment group was treated with aripiprazole.Both groups were compared in terms of clinical efficacy,score of Hamilton Anxiety Scale(HAMA),score of Yale-Brown Obsessive-Compulsive Scale(YBOCS),and levels of tumor necrosis factor-α(TNF-α)and brain-derived neurotrophic factor(BDNF).Results Before treatment,there was no statistically significant difference in HAMA and YBOCS scores between the two groups(P>0.05).After treatment,HAMA score of(8.13±1.79)points and YBOCS score of(9.91±2.05)points in the treatment group were lower than those of(11.85±2.46)and(13.75±3.68)points in the single group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in TNF-αand BDNF levels between the two groups(P>0.05).After treatment,TNF-αof(39.17±4.05)μg/L and BDNF of(39.78±4.22)μg/L in the treatment group were higher than those of(33.82±4.62)and(31.06±4.85)μg/L in the single group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the treatment group was 95.74%,which was higher than that of 76.60%in the single group,and the difference was statistically significant(P<0.05).Conclusion Aripiprazole combined with sertraline has definite efficacy on patients with obsessive-compulsive disorder,which can reduce nerve damage,correct obsessive thinking and behavior,and accelerate the recovery of obsessive-compulsive disorder.This regimen can be promoted.

关 键 词：强迫症 阿立哌唑 舍曲林 精神症状 

分 类 号：R749.7[医药卫生—神经病学与精神病学]