替格瑞洛联合阿托伐他汀治疗急性脑梗死的临床疗效及不良反应  

Efficacy and Side Effects of Ticagrelor Combined with Atorvastatin in Treatment of Acute Cerebral Infarction

作　　者：赵奇[1] 丁希艳[1] ZHAO Qi;DING Xiyan(Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2023年第6期766-770,共5页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(JJKH20200069KJ)。

摘　　要：目的 探讨急性脑梗死(Acute Cerebral Infarction,ACI)治疗中替格瑞洛联合阿托伐他汀的临床疗效,并分析其不良反应.方法 选取146例ACI患者为研究对象,应用随机数字表法将患者分为常规组(73例)和联合组(73例).常规组患者应用阿托伐他汀进行治疗,联合组患者在常规组治疗基础上加用替格瑞洛,比较两组患者的临床疗效、不良反应、血小板功能、血脂水平、炎性因子水平、神经功能以及日常生活自理能力.结果 联合组患者的治疗有效率高于常规组,治疗后血小板计数、血小板抑制率均高于常规组,总胆固醇(TC)、三酰甘油(TG)水平均低于常规组,超敏C反应蛋白(hs-CRP)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)水平均低于常规组,NIHSS评分低于常规组,BI评分高于常规组(均P<0.05).同时,联合组和常规组患者的不良反应发生率比较差异无统计学意义(P>0.05).结论 在临床治疗ACI的过程中,应用替格瑞洛联合阿托伐他汀疗效更佳,并且联合用药在改善血小板功能、神经功能方面具有良好效果,可有效促进患者血脂、炎性因子水平的降低,在一定程度上能提高患者的生活自理能力,具有较高的临床推广价值.Objective To investigate the clinical efficacy of Ticagrelor combined with Atorvastatin in the treatment of Acute Cerebral Infarction(ACI),and to analyze the adverse reactions.Method 146 patients with ACI were selected as the study objects,and the patients were divided into the combined group(73 cases) and the conve-ntional group(73 cases) by random number table method.Patients in the conventional group were treated with Atorvastatin,and patients in the combined group were treated with Ticagrelor on the basis of the conventional group.The clinical efficacy,occurrence of adverse reactions,platelet function,lipid level,inflammatory factor level,neurological function and self-care ability of the two groups were compared.Results The effective rate of treatment in combination group was higher than that in conventional group,the platelet count and platelet inhibition rate after treatment were higher than those in conventional group,the levels of total cholesterol(TC) and Triacylglycerol(TG) were lower than those in conventional group,and the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-2(IL-2) and interleukin-6(IL-6) were lower than those in conventional group.The score of NIHSS was lower than that of conventional group,and the score of BI was higher than that of conventional group(all P<0.05).At the same time,the incidence of adverse reactions between the combined group and the conventional group was compared,and there was no statistical difference(P>0.05).Conclusion In the process of clinical treatment of ACI,the combination of Ticagrelor and Atorvastatin has better efficacy,and has good effects in improving platelet function and nerve function,which can effectively promote the reduction of the levels of blood lipids and inflammatory factors in patients,and strengthen the self-care ability of patients to a certain extent,which has high clinical promotion value.

关 键 词：急性脑梗死 替格瑞洛 阿托伐他汀 

分 类 号：R743[医药卫生—神经病学与精神病学]