恩必普软胶囊治疗短暂性脑缺血发作患者的疗效及对相关因子的影响  

Therapeutic Effect of Enbipu Capsules on Transient Ischemic Attack Patients and its Impact on Related Factors

作　　者：黄亮 贾军 屈兴汉 HUANG Liang;JIA Jun;QU Xinghan(Department of Neurology,Chenggu County Hospital,Hanzhong Shaanxi 723200)

机构地区：[1]汉中市城固县医院神经内科,陕西汉中723200

出　　处：《医学临床研究》2023年第9期1385-1388,共4页Journal of Clinical Research

摘　　要：【目的】探讨恩必普软胶囊治疗短暂性脑缺血发作(TIA)患者的疗效及对相关因子的影响。【方法】110例TIA患者随机分为观察组和对照组,每组55例。在给予常规治疗的基础上,观察组患者口服恩必普软胶囊治疗,对照组口服拜阿司匹林肠溶片治疗,两组均连续治疗14 d。比较两组临床疗效及治疗前后炎症因子[血清超敏C反应蛋白(hs-CPR)、同型半胱氨酸(Hcy)、白介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)]、血液流变学指标[全血黏度低切(LS)、全血黏度高切(HS)、血浆黏度(PV)]、凝血功能指标[纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、神经功能指标[神经功能因子S-100B蛋白(S-100B)、神经元特异性烯醇化酶(NSE)]水平的变化。【结果】观察组总有效率为92.73%(51/55),显著高于对照组的78.18%(43/55),且差异有统计学意义(P<0.05)。两组治疗前各项指标比较,差异均无统计学意义(P>0.05);两组治疗后Hcy、hs-CRP、IL-6、MMP-9较治疗前显著降低(P<0.05),且观察组显著低于对照组(P<0.05);两组治疗后LS、HS、PV较治疗前显著降低(P<0.05),且观察组显著低于对照组(P<0.05);两组治疗后FIB较治疗前显著降低,PT、APTT显著升高(P<0.05),且观察组治疗后FIB显著低于对照组,PT、APTT显著高于对照组(P<0.05);两组治疗后S-100B、NSE较治疗前显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。【结论】恩必普软胶囊治疗TIA疗效显著,可有效抑制炎症反应,对患者的血液流变学、凝血功能及神经功能有明显改善。【Objective】To explore the therapeutic effect of Enbipu capsules on transient ischemic attack(TIA)patients and its impact on related factors.【Methods】A total of 110 TIA patients were randomly divided into two groups,with 55 cases in each group.All patients received conventional treatment for TIA.The observation group was orally administered Enbipu capsules,while the control group was given enteric-coated aspirin tablets.Both groups were treated continuously for 14 days.The clinical efficacy,changes in inflammatory factors[serum hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy),interleukin-6(IL-6),and matrix metalloproteinase-9(MMP-9)],hemorheology indicators[whole blood viscosity at low shear rate(LS),whole blood viscosity at high shear rate(HS),and plasma viscosity(PV)],coagulation function indicators[fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT)],and neurological function indicators[neurofunctional factor S-100B protein(S-100B)and neuron-specific enolase(NSE)]were compared between the two groups.【Results】The overall effective rate in the observation group was 92.73%(51/55),which was significantly higher than the 78.18%(43/55)in the control group with statistically significant difference(P<0.05).There were no significant differences of all indicators in both groups before treatment(P>0.05).Post-treatment levels of Hcy,hs-CRP,IL-6,and MMP-9 in both groups were significantly reduced compared to pre-treatment(P<0.05).And the post-treatment levels of Hcy,hs-CRP,IL-6,and MMP-9 in the observation group were significantly lower than those in the control group after treatment(P<0.05).Compared to before treatment,levels of LS,HS,and PV decreased significantly after treatment in both groups(P<0.05),while LS,HS and PV levels in the observation group were significantly lower than those in the control group(P<0.05).After treatment,FIB in both groups decreased significantly,while PT and APTT increased significantly(P<0.05);And FIB in the observation group after treatment

关 键 词：脑缺血发作 短暂性/药物疗法 软胶囊 治疗结果 

分 类 号：R743.31[医药卫生—神经病学与精神病学]