金属硫蛋白-3联合肿瘤标志物在原发性肝癌TACE术后疗效评估中的应用价值  

The Application Value of Metallothionein-3 Combined with Tumor Markers in the Evaluation of Postoperative Efficacy of TACE for Primary Liver Cancer

作　　者：张莉静 王沛 ZHANG Lijing;WANG Pei(Department of Digestive Endocrinology,The Fourth People's Hospital of Shaanxi,Xi'an Shaanxi 710043)

机构地区：[1]陕西省第四人民医院消化内分泌科,陕西西安710043 [2]西安市高陵区医院消化内科,陕西西安710200

出　　处：《医学临床研究》2023年第9期1396-1399,共4页Journal of Clinical Research

摘　　要：【目的】探讨金属硫蛋白-3(MT-3)联合肿瘤标志物在原发性肝癌经肝动脉灌注化疗栓塞术(TACE)术后疗效评估中的应用价值。【方法】回顾性分析2019年1月至2022年1月陕西省第四人民医院收治的80例TACE治疗的原发性肝癌患者的临床资料,根据患者临床疗效分为控制组和未控制组,统计两组患者年龄、性别、体重指数(BMI)、肝功能Child-Pugh分级、肿瘤部位、肿瘤数目、肿瘤细胞分化程度、肿瘤类型、血清总胆红素(TBIL)、血清肿瘤标志物[细胞角蛋白19片段(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原19-9(CA19-9)]及血清MT-3等临床资料,采用受试者工作特征(ROC)曲线分析血清MT-3联合肿瘤标志物对原发性肝癌患者TACE术后疗效的评估价值。【结果】80例中有65例(81.25%)患者治疗有效,纳为控制组;有15例(18.75%)患者治疗无效,纳为未控制组。两组性别、肿瘤直径、肿瘤数目、肿瘤部位、肿瘤细胞分化程度、肿瘤类型、肝硬化、肝功能Child-Pugh分级占比及年龄、BMI、TBIL、CA19-9、CEA比较,差异无统计学意义(P>0.05);未控制组CYFRA21-1、SCC、AFP水平均高于控制组(P<0.05),MT-3水平均低于控制组(P<0.05)。ROC曲线分析结果显示:CYFRA21-1、SCC、AFP、MT-3均对原发性肝癌患者TACE术后疗效有一定的预测价值。【结论】CYFRA21-1、SCC、AFP、MT-3对原发性肝癌患者TACE术后疗效有一定的预测价值,且联合预测价值更高,临床医师应当予以密切关注。【Objective】To explore the application value of metallothionein-3(MT-3)combined with tumor markers in evaluating the postoperative efficacy of transcatheter arterial chemoembolization(TACE)for primary liver cancer.【Methods】A retrospective analysis was conducted on the clinical data of 80 TACE treated primary liver cancer patients admitted to the Fourth People's Hospital of Shaanxi Province from January 2019 to January 2022.They were divided into a control group and an uncontrolled group based on their clinical efficacy.Clinical data such as Age,gender,body mass index(BMI),Child Pugh grading of liver function,tumor site,number of tumors,degree of tumor cell differentiation,tumor type,serum total bilirubin(TBIL),and serum tumor markers[CYFRA21-1,Squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohydrate antigen 19-9(CA19-9)],and serum MT-3 of two groups of patients were collected;The evaluation value of serum MT-3 combined with tumor markers in the postoperative efficacy of TACE in patients with primary liver cancer were analyzed using the receiver operating characteristic(ROC)curve.【Results】Among the 80 cases,65 patients(81.25%)were effectively treated and included in the control group;15 patients(18.75%)were included in the uncontrolled group due to ineffective treatment.There was no statistically significant difference(P>0.05)between the two groups in terms of gender,tumor diameter,number of tumors,tumor location,degree of tumor cell differentiation,tumor type,liver cirrhosis,proportion of Child Pugh grading of liver function,age,BMI,TBIL,CA19-9,CEA;The levels of CYFRA21-1,SCC,and AFP in the uncontrolled group were higher than those in the control group(P<0.05),while the levels of MT-3 were lower than those in the control group(P<0.05).The ROC curve analysis results show that CYFRA21-1,SCC,AFP,and MT-3 all have certain predictive value for the postoperative efficacy of TACE in patients with primary liver cancer.【Conclusions】CYFRA21-1,SCC,AFP,and MT-3 hav

关 键 词：肝肿瘤 金属硫蛋白 生物标记 肿瘤 化学栓塞 治疗性 

分 类 号：R735.7[医药卫生—肿瘤]