115例女性精神分裂症患者非酒精性脂肪性肝病患病率及其危险因素分析  

Prevalence rate and risk factor analysis of nonalcoholic fatty liver disease in 115 female patients with schizophrenia

作　　者：虞莹 赵坚[2] 金亚玲[3] 谢群[4] 姚登福 姚敏[1] Yu Ying;Zhao Jian;Jin Yaling;Xie Qun;Yao Dengfu;Yao Min(Research Center of Clinical Medicine,Affiliated Hospital&Department of Immunology,Medical School,Nantong University,Nantong 226001,China;Nantong Center for Disease Control and Prevention,Nantong 226001,China;Departments of Psychiatry&Laboratory,Nantong 4th People's Hospital,Nantong 226005,China;Department of Infectious Diseases,Hai'an People's Hospital,Haian 226500,China)

机构地区：[1]南通大学附属医院临床医学研究中心和医学院免疫学系,南通226001 [2]南通市疾病预防控制中心,南通226001 [3]南通市第四人民医院精神科和检验科,南通226005 [4]海安市人民医院感染性疾病科,海安226500

出　　处：《中华肝脏病杂志》2023年第9期947-953,共7页Chinese Journal of Hepatology

基　　金：国家自然科学基金面上项目(31872738);江苏省卫计委(Z2022094);南通市科技局(MS22021027);南通市卫计委项目(MB2020045)。

摘　　要：目的调查精神分裂症(SCZ)患者非酒精性脂肪性肝病(NAFLD)发生率及其危险因素分析。方法经南通市第四人民医院伦理委员会同意,分析40岁以上具有完整临床资料115例SCZ女性患者中NAFLD发病率,以体检健康者(n=95,女性,年龄40岁以上)为对照组。采用自然语言处理技术提取患者电子病历系统中相关资料,与NAFLD相关的人体质量指数、丙氨酸转氨酶、甘油三酯、低密度脂蛋白、瘦素和脂联素等建立模型,以logistic回归分析评估女性SCZ患者精神症状、生理和生物化学指标,评估对NAFLD预测价值。结果SCZ组NAFLD患病率为55.7%(64/115),显著高于(χ^(2)=18.335,P<0.001)对照组(26.3%,25/95);预测模型显示年龄、丙氨酸转氨酶、甘油三酯、低密度脂蛋白、瘦素、脂联素、人体质量指数与女性SCZ患NAFLD者显著相关;在自然语言处理法搜索语言模型中,兴奋征(动作多:不受控制的乱跑行为)和情绪冷漠与女性SCZ患NAFLD者显著相关。其中年龄、丙氨酸转氨酶、甘油三酯、低密度脂蛋白、瘦素、人体质量指数是SCZ患NAFLD的危险因素,脂联素水平和不受控制的乱跑行为是保护因素。结论中老年女性SCZ患者中NAFLD发生率较高,自然语言处理法有助于自动识别SCZ合并NAFLD危险因素,具有预测和辅助诊断价值。Objective To investigate the incidence rate and risk factors of nonalcoholic fatty liver disease(NAFLD)in patients with schizophrenia(SCZ).Methods The incidence rate of NAFLD in 115 females with SCZ over 40 years of age with complete clinical data was analyzed with the consent of the Ethics Committee of Nantong Fourth People's Hospital.A physical examination report of healthy subjects(n=95,female,age 40 years old or older)was taken as the control group.Natural language processing technology was used to extract relevant data from the patient's electronic medical record system.Body mass index,alanine aminotransferase,triglycerides,low-density lipoprotein,leptin,and adiponectin were used to establish a human NAFLD-related model.Logistic regression analysis was used to evaluate the psychiatric symptoms,and physiological and biochemical indexes for the predictive value of NAFLD in female patients with SCZ.Results The prevalence of NAFLD was significantly higher in the SCZ group(55.7%,64/115)than that in the control group(26.3%,25/95)(χ^(2)=18.335,P<0.001).The prediction model showed that age,alanine aminotransferase,triglycerides,low-density lipoprotein,leptin,adiponectin,and body mass index were significantly correlated with NAFLD in females with SCZ.In the natural language processing search language model,arousal intensity(movements:uncontrolled running behavior)and emotional apathy were strongly linked to female patients with SCZ with NAFLD.Age,alanine aminotransferase,triglycerides,low-density lipoprotein,leptin,and body mass index were risk factors for SCZ to develop NAFLD,and adiponectin levels and uncontrolled running behavior were protective factors.Conclusion The incidence rate of NAFLD is high in middle-aged and elderly females with SCZ.Natural language processing can help to automatically identify the risk factors for SCZ combined with NAFLD and has predictive and auxiliary diagnostic value.

关 键 词：精神分裂症 非酒精性脂肪性肝炎 自然语言处理 危险因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R575.5[医药卫生—临床医学]