能量分布均匀性对恒功率下多极射频诱导胶原蛋白分泌的影响  

Effects of Energy Distribution Uniformity on Collagen Secretion Induced by Multipolar Radiofrequency at Constant Power

作　　者：徐晗 张浩 刘定新 谢楷 邵明绪 Xu Han;Zhang Hao;Liu Dingxin;Xie Kai;Shao Mingxu(School of Aerospace Science and Technology Xidian University Xi’an 710071,China;Centre for Plasma Biomedicine Xi’an Jiaotong University Xi’an 710049,China;Xi’an Shijiusui Information Technology Co.Ltd Xi’an 710076,China)

机构地区：[1]西安电子科技大学空间科学与技术学院,西安710071 [2]西安交通大学等离子体生物医学研究中心,西安710049 [3]西安拾玖岁信息科技有限公司,西安710076

出　　处：《电工技术学报》2023年第S01期247-256,共10页Transactions of China Electrotechnical Society

基　　金：国家自然科学基金(52107162);陕西省科技发展计划(2022CGBX-12,2022KXJ-57);中央高校基本科研业务费专项资金(QTZX23064)资助项目。

摘　　要：针对多极射频的电极极性排布模式开展研究,建立仿真模型分析皮肤组织中射频能量分布和热量分布随不同处理模式的变化规律,并通过细胞实验和动物实验定量分析了能量分布均匀性对恒功率下多极射频诱导胶原蛋白分泌的影响。结果表明,正、负电极交错排列模式下,多极射频作用于皮肤组织的电流密度均值、能量分布均匀性和热量分布均匀性相对最优。多极射频处理可有效促进体外培养的皮肤成纤维HFF-1细胞增殖并提升细胞活力,同时该应用效果与射频能量分布均匀性正相关。不同电极极性排布模式下多极射频诱导胶原蛋白分泌的效果有显著差异,能量分布均匀性越高,成纤维细胞分泌胶原蛋白量及大鼠皮肤胶原蛋白层厚度增加越明显。以上结果为多极射频技术的临床研究提供了理论和实验支撑。Radiofrequency(RF)treatments,where heat selectively acts on skin tissue,are widely used to treat and improve wrinkles,capillary dilation,hyperpigmentation and other skin problems.The penetration depth and distribution uniformity of RF energy can beregulated by adjusting the electrode frequency,phase and polarity of multipolar RF parameters,which can significantly improve the energy efficiency compared withmonopolar RF and bipolar RF.In recent years,parameters such as electrode diameter,frequency or phase of multipolar RF have been extensively studied,but the effect of different electrode polarity arrangements on the therapeutic effect has rarely been reported.The aim of this paper is to investigate the effect of the electrode polarity arrangement modes of multipolar RF on the uniformity of energy distribution and its biological effect on skin application.Firstly,a three-dimensional simulation model isestablished using COMSOL Multiphysics software to investigate the effect of three electrode polarity arrangement modes of multipolar RF on energy distribution and heat distribution in skin tissue at constant power.In mode 1,the polarity of each row of electrodes is the same and the polarity of two adjacent rows is opposite.In mode 2,the positive and negative electrodes are staggered.In mode 3,each row/column has two electrodes of the same polarity,while the top and bottom electrodes have opposite polarities.The simulation model couples several physical field modules,including electric field,solid heat transfer and electromagnetic heat,where the electrical and thermal parameters of the skin tissue are referred to a database of fundamental physics experiments.Secondly,in vitro cultured human-derived skin fibroblast HFF-1 cells are treated in three treatment modes of multipolar RF.Cell proliferation,cell activity,and collagen secretion are quantified in the cell biology experiments.Finally,rat dorsal skin is treated to study the effect of different electrode polarity arrangement modes on collagen secretion and skin path

关 键 词：多极射频 能量分布 热量分布 胶原蛋白 恒功率 

分 类 号：TM15[电气工程—电工理论与新技术]