番茄红素缓解动物线粒体损伤的研究进展  

Research progress of lycopene alleviating mitochondrial damage in animals

作　　者：郝振芳[1,2] 蔡子慧 杜娟娟 陈云贺 陈凤娟 姜义宝[1] 杨旭[1] 张丛 HAO Zhenfang;CAI Zihui;DU Juanjuan;CHEN Yunhe;CHEN Fengjuan;JIANG Yibao;YANG Xu;ZHANG Cong(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China;College of Animal Husbandry Engineering,Henan Vocational College of Agriculture,Zhengzhou 451450,China)

机构地区：[1]河南农业大学动物医学院,河南郑州450046 [2]河南农业职业学院牧业工程学院,河南郑州451450

出　　处：《河南农业大学学报》2023年第5期736-743,共8页Journal of Henan Agricultural University

基　　金：国家自然科学基金青年基金项目(32102739,32202877);河南省高等学校重点科研项目(22A230010,23A230008);河南农业大学科技创新基金(KJCX2021A06)。

摘　　要：从线粒体结构、线粒体氧化损伤、线粒体自噬、线粒体动力学及生物发生等分子机制角度,综述了番茄红素(lycopene,LYC)对动物线粒体损伤的保护作用及分子机制,总结了现阶段LYC保护线粒体损伤的研究进展。今后应在提高LYC生物利用度、丰度及探究LYC缓解线粒体损伤的分子机制方面进行进一步深入研究,为推进LYC在动物疾病治疗和预防中的应用提供理论依据和参考。From the perspective of mitochondrial structure,mitochondrial oxidative damage,mito-phagy,mitochondrial dynamics and biogenesis,this article reviewed the protective effects and molecular mechanism of lycopene(LYC)on animal mitochondrial damage,and summarized the current research progress on the protection of LYC against mitochondrial damage.In the future,further researches should be investigated to improve the bioavailability and abundance of LYC and the molecular mechanisms of LYC to alleviate mitochondrial damage,providing theoretical basis and reference for promoting the application of LYC in the treatment and prevention of animal diseases.

关 键 词：动物线粒体 番茄红素 线粒体损伤 线粒体自噬 线粒体动力学 线粒体生物发生 

分 类 号：S859.81[农业科学—临床兽医学]