m^(6)A修饰与阿尔茨海默病的研究进展  

Research advances in m^(6)A modification and Alzheimer disease

作　　者：刘丹丹 秦合伟 孙孟艳[1] 王梦楠 高洋 牛雨晴 宋雪梅 LIU Dandan;QIN Hewei;SUN Mengyan;WANG Mengnan;GAO Yang;NIU Yuqing;SONG Xuemei(School of Rehabilitation,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Rehabilitation Medicine,the Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南中医药大学康复医学院,河南郑州450046 [2]河南中医药大学第二附属医院康复医学科,河南郑州450002

出　　处：《中国病理生理杂志》2023年第10期1891-1897,共7页Chinese Journal of Pathophysiology

基　　金：中原英才计划中原青年拔尖人才项目资助(豫组通[2021]44号);河南省中医药拔尖人才培养项目资助(豫卫中医函[2021]15号);河南省中医学“双一流”创建科学研究专项课题(No.HSRP-DFCTCM-2023-3-27)。

摘　　要：N^(6)-腺苷甲基化(N^(6)-adenosine methylation,m^(6)A)是将S-腺苷甲硫氨酸提供的甲基添加到腺苷N^(6)位点的表观遗传修饰,在20世纪70年代被鉴定出来,占成人大脑中全部信使RNA(messenger mRNA)碱基甲基化的80%以上^([1]),还可发生在微小RNA、长链非编码RNA(long noncoding RNA,lncRNA)、环状RNA(circular RNA,circRNA)、转运RNA(transfer RNA,tRNA)和核糖体RNA中^([2])。As a common and heterogeneous type of neurodegenerative dementia with a long course and com‐plex pathogenesis,Alzheimer disease(AD)mostly occurrs in middle-aged and elderly people.N^(6)-adenosine methylation(m^(6)A)is the most abundant mRNA modification in eukaryotes with dynamic and reversible features.A large number of studies have shown that enzymes involved in m^(6)A modification could recognize RRACH sequences in target RNA and medi‐ate post-transcriptional translation or degradation of target RNA,as a key molecular factor in the pathogenesis of AD.This paper reviewed the involvement of m^(6)A modification in amyloid plaque,tau protein hyperphosphorylation,microglial acti‐vation-mediated neuroinflammation,and glial and synaptic plasticity,so as to reveal the existing early evidence of m^(6)A's involvement in the pathological mechanism,thus providing theoretical support for seeking early biomarkers and experimen‐tal evidence for AD in the future.

关 键 词：m^(6)A修饰 阿尔茨海默病 Β-淀粉样肽 高通量测序 

分 类 号：R742[医药卫生—神经病学与精神病学] R363[医药卫生—临床医学] Q756[生物学—分子生物学]