大家畜多能干细胞的研究进展与应用前景  

Research Progress and Application Prospect of Livestock Pluripotent Stem Cells

作　　者：罗睿杰 曹素英[1] LUO Ruijie;CAO Suying(College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China)

机构地区：[1]北京农学院动物科学技术学院,北京102206

出　　处：《畜牧兽医学报》2023年第10期4003-4015,共13页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：北京自然科学基金(6192005);国家自然科学基金(31601941)。

摘　　要：多能干细胞具有无限增殖能力,可以分化产生三胚层各种组织细胞,在生物医药、动物育种等领域有广泛应用前景。大家畜干细胞可以加速育种进程,代替小鼠作为医学研究模型,生产细胞培养肉等。然而,由于家畜与人、小鼠等之间存在较大的种间差异,大家畜多能干细胞建系进程相对滞后。目前稳定的猪多能干细胞已经成功建系,而牛、羊、马等其他家畜的多能干细胞系仍存在不足。本文综述了大家畜胚胎干细胞和诱导多能干细胞建系的研究进展,并对大家畜多能干细胞在干细胞基础研究、家畜繁殖、生物医学、食品生产等领域的应用前景进行了展望。Pluripotent stem cells(PSC)refer to cells with unlimited proliferation capacity and can differentiate to produce various tissue cells of three germ layers.They have wide application prospects in biological medicine,animal breeding and other fields.Livestock stem cells can be used to accelerate the process of breeding,generate models for biomedical research instead of mice,and produce cultured meat,etc.However,due to the interspecies differences between livestock and humans or mice,the progress of livestock pluripotent stem cell establishment is relatively lagging.At present,stable porcine PSC lines have been successfully established,while PSC lines of other livestock such as bovine,sheep,goat and horse still remain insufficient.In this review,we summarize the progress made in embryonic stem cells and induced pluripotent stem cells established in domestic animals wene summerized,and also give as well as an outlook on the future applications of pluripotent stem cells in stem cell basis,livestock breeding and reproduction,biomedical science,and food industry was given.

关 键 词：大家畜 胚胎干细胞 诱导多能干细胞 家畜繁殖 生物医学 食品生产 

分 类 号：S814[农业科学—畜牧学]