ADAP2在胶质瘤患者中的预后价值及功能研究  

Prognostic value and function of ADAP2 in patients with glioma

作　　者：张超[1] 王钰[1] 邵尉 周冬瑞 侯仕强 余东 王帅[1] 林宁 ZHANG Chao;WANG Yu;SHAO Wei(Department of Neurosurgery,The Affiliated Chuzhou Hospital of Anhui Medical University,The First People's Hospital of Chuzhou,Chuzhou 239000,China)

机构地区：[1]安徽医科大学附属滁州医院,滁州市第一人民医院神经外科,滁州239000

出　　处：《临床神经外科杂志》2023年第5期508-514,共7页Journal of Clinical Neurosurgery

基　　金：安徽医科大学学科建设项目(外科学与药理学共建项目);安徽省高校自然科学研究重大项目(KJ2021ZD0036);安徽省高校自然科学研究重点项目(2022AH050769);安徽医科大学青年自然科学基金项目(2020xkj080)。

摘　　要：目的分析ADAP2在脑胶质瘤中的预后价值和对胶质瘤迁移和侵袭的影响,并探索其可能机制。方法应用生物信息学分析ADAP2在胶质瘤中的差异性表达及其预后价值,并探索ADAP2对胶质瘤患者的潜在致癌机制。使用胶质瘤U87细胞系评估ADAP2敲除后对细胞迁移和侵袭的影响。结果ADAP2在恶性程度更高的胶质瘤亚型中富集,与免疫和炎症过程正相关,是胶质瘤患者的独立预后因素。敲低ADAP2后胶质瘤细胞的迁移和侵袭能力下降。结论ADAP2与胶质瘤的临床病理特征密切相关,通过与免疫细胞相互作用促进胶质瘤的进展,高表达ADAP2能促进胶质瘤细胞迁移和侵袭,是胶质瘤免疫治疗和精准诊断的潜在靶点。Objective To analyze the prognostic value of ADAP2 in gliomas and its effect on glioma migration and invasion,and to explore its possible mechanisms.Methods Bioinformatics was applied to analyze the differential expression of ADAP2 in gliomas and its prognostic value,and to explore the potential oncogenic mechanisms of ADAP2 in glioma patients.The effects of ADAP2 knockdown on cell migration and invasion were assessed using the glioma U87 cell line.Results ADAP2 was enriched in more malignant glioma subtypes,positively correlates with immune and inflammatory processes,and was an independent prognostic factor for glioma patients.Migration and invasion of glioma cells were decreased after knockdown of ADAP2.Conclusions ADAP2 is closely related to the clinicopathological features of glioma and promotes the progression and evolution of glioma by interacting with immune cells.High expression of ADAP2 promotes the migration and invasive ability of glioma cells,and is a potential target for glioma immunotherapy and precision diagnosis.

关 键 词：ADAP2 胶质瘤 免疫 预后 

分 类 号：R739.41[医药卫生—肿瘤]