信号通路在胃癌转移中作用的研究进展  

Research progress of signaling pathways in gastric cancer metastasis

作　　者：杨蛟洋 舒格格 李东宝[1] 周进[1] YANG Jiaoyang;SHU Gege;LI Dongbao;ZHOU Jin(Department of Gastrointestinal Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215129,China)

机构地区：[1]苏州大学附属第一医院普外科胃肠外科,江苏苏州215129

出　　处：《基础医学与临床》2023年第11期1707-1712,共6页Basic and Clinical Medicine

基　　金：国家自然科学基金(81871952);江苏省自然科学基金(BK20221242);苏州市第五批姑苏卫生人才培养项目(GSWS2019008)。

摘　　要：细胞中不同的信号通路交互作用、互相调控形成一个动态的信号转导网络,参与肿瘤的发生发展,而胃癌的转移就是由各种信号通路调节影响的结果。肿瘤转移通常在临床上与较差的患者预后直接相关,因此深入研究影响胃癌转移的信号通路对晚期胃癌患者的治疗可提供帮助。The interaction and mutual regulation of different signaling pathways in cells form a dynamic signal transduction network,which is involved in the development of tumors,as the distant metastasis of gastric cancer is the result of regulation and influence of various signaling pathways.Cancer metastasis is often directly associated with poor prognosis,thus in-depth study of the signaling pathway affecting gastric cancer metastasis is essential strategy to optimize the treatment of advanced gastric cancer patients.

关 键 词：胃癌 转移 转化生长因子β(TGFβ) 磷脂酰肌醇3激酶(PI3K) 信号通路 

分 类 号：R735.2[医药卫生—肿瘤]