空间组学技术在头颈部肿瘤个体化诊疗中的研究进展  

Advances of spatial omics in the individualized diagnosis and treatment of head and neck cancer

作　　者：徐晨阳 王寅 魏东敏[1] 李文明[1] 钱晔[1] 潘新良[1] 雷大鹏[1] XU Chenyang;WANG Yin;WEI Dongmin;LI Wenming;QIAN Ye;PAN Xinliang;LEI Dapeng(Department of Otorhinolaryngology,Qilu Hospital of Shandong University,National Health Commission Key Laboratory of Otorhinolaryngology,Jinan,250012,China)

机构地区：[1]山东大学齐鲁医院耳鼻咽喉科,国家卫生健康委员会耳鼻喉科学重点实验室(山东大学),济南250012

出　　处：《临床耳鼻咽喉头颈外科杂志》2023年第9期729-733,739,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:82071918)。

摘　　要：空间组学是继单细胞测序技术之后的另一个生物技术研究热点,其能够弥补单细胞测序技术无法获取细胞空间分布信息的缺陷。空间组学主要研究细胞在组织样品中的相对位置关系,以揭示细胞空间分布关系对疾病的影响。近年来,空间组学在头颈肿瘤的发生机制、靶点探索、药物研发等诸多方面有了新的进展,本文围绕空间组学技术在头颈肿瘤诊疗多方面的最新进展做一概述。Spatialomics is another research hotspot of biotechnology after single-cell sequencing technology,which can make up for the defect that single-cell sequencing technology can not obtain cell spatial distribution information.Spatialomics mainly studies the relative position of cells in tissue samples to reveal the effect of cell spatial distribution on diseases.In recent years,spatialomics has made new progress in the pathogenesis,target exploration,drug development and many other aspects of head and neck tumors.This paper summarizes the latest progress of spatialomics in the diagnosis and treatment of head and neck cancer.

关 键 词：空间组学 头颈肿瘤 个体化诊疗 

分 类 号：R739.6[医药卫生—肿瘤]