^(18)F-PSMA PET/CT探索不良生活方式对初诊前列腺癌转移的预测价值  

The predictive value of unhealthy lifestyle for the metastasis of newly diagnosed prostate cancer based on ^(18)F-PSMA PET/CT

作　　者：郑艳 王卓楠 郑安琪 高俊刚[2] 段小艺[2] ZHENG Yan;WANG Zhuonan;ZHENG Anqi;GAO Jungang;DUAN Xiaoyi(Department of Nuclear Medicine,the First Affiliated Hospital,and College of Clinical Medicine of He'nan University of Science and Technology,Luoyang,He'nan Province 471003,China;PET/CT Center,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院核医学科,河南洛阳471003 [2]西安交通大学第一附属医院PET/CT室,陕西西安710061

出　　处：《实用放射学杂志》2023年第9期1467-1470,共4页Journal of Practical Radiology

基　　金：西安交通大学第一附属医院临床研究项目(XJTU1AF-CRF2020-008);西安交通大学第一附属医院新医疗新技术项目(XJYFY-2019J1)。

摘　　要：目的探讨吸烟、饮酒、肥胖对初诊前列腺癌(PCa)转移风险的预测价值.方法回顾性收集确诊PCa、未行治疗的203例患者的临床资料,以^(18)F-前列腺特异性膜抗原(PSMA)-1007 PET/CT成像作为PCa转移与否的判断标准,比较不良生活方式与转移的关系,采用单因素及多因素二元logistic回归分析法寻找独立预测初诊PCa转移风险的不良生活方式,并进一步进行分层分析.结果吸烟是预测初诊PCa转移的独立危险因素[比值比(OR)=2.281,P=0.013],增加吸烟和/或饮酒因素发生转移的风险增高,差异有统计学意义(OR=2.235,P=0.023),吸烟≥30年者转移风险高于吸烟<30年者,差异有统计学意义(P=0.016).饮酒、体质量指数(BMI)与初诊PCa转移风险无关(P>0.05).结论^(18)F-PSMA PET/CT显示吸烟能够预测初诊PCa转移风险,吸烟≥30年患者转移风险更高,为临床个体化诊疗提供参考.Objective To investigate the predictive value of smoking,alcohol consumption and obesity for metastatic risk of newly diagnosed prostate cancer(PCa).Methods The clinical data of 203 patients with PCa diagnosed and untreated were retrospectively collected,^(18)F-prostatic specific membrane antigen(PSMA)-1007 PET/CT imaging was used as the criterion for the diagnosis of PCa metastasis,and the relationship between unhealthy lifestyle and PCa metastasis was compared.Univariate and multivariate binary logistic regression analysis was used to find out the unhealthy lifestyle that could independently predict the risk of PCa metastasis,and further stratified analysis was performed.Results Smoking was an independent risk factor for predicting metastasis of newly diag-nosed PCa[odds ratio(OR)=2.281,P=0.013].The risk of metastasis increased when smoking and/or alcohol consumption increased,and the difference was statistically significant(OR=2.235,P=0.023).The risk of metastasis was higher in those who had smoked for≥30 years than those who had smoked<30 years,and the difference was statistically significant(P=0.016).Alcohol consump-tion and body mass index(BMI)were not associated with the risk of metastasis of newly diagnosed PCa(P>0.05).Conclusion ^(18)F-PSMA PET/CT shows that smoking can predict the risk of metastasis of newly diagnosed PCa,and the risk of metastasis is higher in patients who have smoked for≥30 years,which provides a reference for clinical individualized diagnosis and treatment.

关 键 词：前列腺癌 不良生活方式 转移 18F-前列腺特异性膜抗原 正电子发射断层显像/计算机体层成像 

分 类 号：R737.25[医药卫生—肿瘤] R814.42[医药卫生—临床医学]