4’-取代核苷类似物的合成及抗病毒活性研究进展  

Synthesis and Antiviral Activity of 4′-Substituted Nucleoside Analogues

作　　者：王艺儒 陈默芳 陶林 席宇 WANG Yi-ru;CHEN Mo-fang;TAO Lin;XI Yu(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang,Harbin 150076,China;Beijing Daxing Xingye Dental Hospital,Beijing 102600,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]黑龙江省预防与治疗老年病药物研究重点实验室,黑龙江哈尔滨150076 [3]北京大兴兴业口腔医院,北京102600

出　　处：《精细化工中间体》2023年第4期5-10,31,共7页Fine Chemical Intermediates

摘　　要：病毒感染作为主要传染性疾病,传播迅速,可引起爆发性疾病。而核苷类似物与核苷酸结构相似,被病毒逆转录酶错误识别后,可终止DNA复制,因此核苷类似物具有良好的抗病毒活性,可覆盖同一病毒大部分毒株,在核苷类似物4’-修饰后其电负性、空间位阻或脂溶性改变,可提高其抗病毒活性和稳定性。总结了引入4’-修饰基团的合成方法及其对抗病毒活性的影响。Viral infections are the main contagious diseases,spreading rapidly and causing outbreaks.Nucleoside analogues,which have similar structures to nucleotides,can terminate DNA replication when wrongly recognized by viral reverse transcriptase.Therefore,nucleoside analogues exhibit excellent antiviral activity and can cover most strains of the same virus.By modifying the 4'-nucleoside analogues,their electronegativity,steric hindrance,or lipophilicity can be altered,resulting in enhanced antiviral activity and stability.The synthetic methods of introducing 4'-substituent groupsand their effects on antiviral activity are summarized.

关 键 词：结构修饰 核苷类似物 抗病毒 

分 类 号：R914[医药卫生—药物化学]