儿童常用抗癫痫发作药处方审核建议  

Recommendations for prescription review of commonly used anti-seizure medications in treatment of children with epilepsy

作　　者：秦倩倩[1] 丁倩 刘晓玲 蔡和平 陈泽彬[5] 郝丽娜[6] 黄亮[7] 贾运涛[8] 菅凌燕[9] 李中 梁华 刘茂昌 卢庆红[13] 莫小兰 缪静 任艳丽[16] 孙华君 孙燕燕[18] 许静[19] 闫美兴 杨莉[21] 张胜男 张顺国[22] 赵昕[23] 邓劼[24] 方方[24] 高丽 韩虹[26] 黄绍平[27] 蒋莉[28] 李保敏[29] 梁建民[30] 廖建湘[31] 刘智胜[32] 罗蓉[33] 彭镜[34] 孙丹[32] 王华[35] 吴晔[36] 杨健[37] 张玉琴[38] 钟建民[39] 周水珍 邹丽萍[41,42] 姜玉武 王晓玲[2] Qin Qianqian;Ding Qian;Liu Xiaoling;Cai Heping;Chen Zebin;Hao Lina;Huang Liang;Jia Yuntao;Jian Lingyan;Li Zhong;Liang Hua;Liu Maochang;Lu Qinghong;Mo Xiaolan;Miao Jing;Ren Yanli;Sun Huajun;Sun Yanyan;Xu Jing;Yan Meixing;Yang Li;Zhang Shengnan;Zhang Shunguo;Zhao Xin;Deng Jie;Fang Fang;Gao Li;Han Hong;Huang Shaoping;Jiang Li;Li Baomin;Liang Jianmin;Liao Jianxiang;Liu Zhisheng;Luo Rong;Peng Jing;Sun Dan;Wang Hua;Wu Ye;Yang Jian;Zhang Yuqin;Zhong Jianmin;Zhou Shuizhen;Zou Liping;Jiang Yuwu;Wang Xiaoling(Department of Pharmacy,Shanxi Children′s Hospital(Maternal and Child Health Hospital),Taiyuan 030013,China;Department ofPharmacy,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing100045,China;Department of Pharmacy,Henan Children′s Hospital,Zhengzhou 450018,China;Department of Clinical Pharmacy,Anhui Children′s Hospital,Anhui Branch of Fudan University Affiliated Children Hospital,Hefei 230000,China;Department of Pharmacy,ShenzhenChildren′s Hospital,Shenzhen 518026,China;Department of Pharmacy,Children′s Hospital Affiliated to Shandong University(JinanChildren′s Hospital),Jinan 250022,China;Department of Pharmacy,Evidence-Based Pharmacy Center,West China Second UniversityHospital,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Chengdu610041,China;Department of Pharmacy,Children′s Hospital of Chongqing Medical University,Chongqing 400014,China;Department ofPharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Pharmacy,Dalian Women and Children′sMedical Group,Dalian 116012,China;Department of Pharmacy,Women and Children Hospital Affiliated to the School of Medicine,Universityof Electronic Science and Technology of China,Chengdu 611731,China;Department of Pharmacy,Wuhan Children′s Hospital,Tongji MedicalCollege,Huazhong University of Science and Technology,Wuhan 430016,China;Department of Pharmacy,Jiangxi Provincial Children′sHospital,Nanchang 330006,China;Departmen

机构地区：[1]山西省儿童医院(妇幼保健院)药剂科,太原030013 [2]国家儿童医学中心,首都医科大学附属北京儿童医院药学部,北京100045 [3]河南省儿童医院药学部,郑州450018 [4]复旦大学附属儿科医院安徽医院(安徽省儿童医院)临床药学部,合肥230000 [5]深圳市儿童医院药学部,深圳518026 [6]山东大学附属儿童医院(济南市儿童医院)药学部,济南250022 [7]四川大学华西第二医院药学部,四川大学华西第二医院循证药学中心,出生缺陷与妇儿疾病教育部重点实验室,成都610041 [8]重庆医科大学附属儿童医院药学部,重庆400014 [9]中国医科大学附属盛京医院药学部,沈阳110004 [10]大连市妇女儿童医疗中心(集团)药学部,大连116012 [11]电子科技大学医学院附属妇女儿童医院,成都市妇女儿童中心医院药学部,成都611731 [12]华中科技大学同济医学院附属武汉儿童医院药学部,武汉430016 [13]江西省儿童医院临床药学科,南昌330006 [14]广州市妇女儿童医疗中心药学部,广州510620 [15]浙江大学医学院附属儿童医院药剂科,国家儿童健康与疾病临床医学研究中心,杭州310052 [16]郑州大学第三附属医院药学部,郑州450052 [17]上海市儿童医院,上海交通大学医学院附属儿童医院药学部,上海200062 [18]天津市儿童医院药剂科,天津300134 [19]南京医科大学附属儿童医院药学部,南京210008 [20]青岛大学附属妇女儿童医院药学部,青岛266034 [21]首都医科大学附属北京天坛医院药学部,北京100070 [22]国家儿童医学中心,上海交通大学医学院附属上海儿童医学中心药剂科上海200127 [23]湖南省儿童医院药学部,长沙410007 [24]国家儿童医学中心,首都医科大学附属北京儿童医院神经内科,北京100045 [25]郑州大学人民医院,河南省人民医院儿科,郑州450003 [26]山西省儿童医院(妇幼保健院)神经内科,太原030013 [27]西安交通大学第二附属医院儿科,西安710004

出　　处：《中华实用儿科临床杂志》2023年第10期740-748,共9页Chinese Journal of Applied Clinical Pediatrics

摘　　要：抗癫痫发作药(anti-seizure medications,ASMs)是癫痫治疗的主要方法,ASMs种类繁多,作用机制复杂,药师在处方审核时存在一定难度。现从ASMs的适应证、剂型/给药途径、用法用量适宜性、联合用药及药物相互作用、长期处方审核、患儿的病理生理个体差异以及合并常见癫痫共患病时的药物选择等方面提出建议,供广大医师、药师参考。Anti-seizure medications(ASMs)are the main therapy for epilepsy.There are many kinds of ASMs with complex mechanism of action,so it is difficult for pharmacists to examine prescriptions.This paper put forward some suggestions on the indications,dosage forms/routes of administration,appropriateness of usage and dosage,combined medication and drug interaction,long-term prescription review,individual differences in pathophysiology of children,and drug selection when complicated with common epilepsy,for the reference of doctors and pharmacists.

关 键 词：抗癫痫发作药 癫痫 处方审核 建议 

分 类 号：R95[医药卫生—药学]