高原低氧环境对肠道菌群影响的研究进展  

Research advances in effect of high-altitude hypoxic environment on intestinal flora

作　　者：杜文琪 闫馨[2] 马燕 张伟[1,2,3,4] DU Wenqi;YAN Xin;MA Yan;ZHANG Wei(Research Center for High Altitude Medicine,Qinghai University School of Medicine,Xining 810001,Qinghai Province,China;Qinghai University School of Medicine,Xining 810001,Qinghai Province,China;Key Laboratory for Application of High Altitude Medicine in Qinghai Province,Qinghai University,Xining 810001,Qinghai Province,China;Qinghai-Utah Joint Research Key Lab for High Altitude Medicine,Qinghai University School of Medicine,Xining 810001,Qinghai Province,China)

机构地区：[1]青海大学高原医学研究中心,青海西宁810001 [2]青海大学医学部,青海西宁810001 [3]高原医学教育部重点实验室,青海西宁810001 [4]青海-犹他高原医学联合重点实验室,青海西宁810001

出　　处：《解放军医学院学报》2023年第8期933-937,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(32260222);青海大学青年科研基金项目(2021-QYY-2)。

摘　　要：肠道菌群的动态平衡是维持人体健康的重要标志之一。环境是影响肠道菌群组成多样性和丰度的重要因素,肠道菌群可以通过改变其组成来适应环境的变化。世代生活在低氧环境下的人群会发生特定基因的改变,从而会影响肠道菌群的多样性和丰度。高原低氧环境与肠道菌群之间相互联系的研究对低氧环境人群的健康具有重要意义,目前关于低氧环境对于肠道菌群组成影响的具体作用机制研究未见报道。本文重点综述高原低氧环境下人体肠道菌群的变化及其可能原因的研究进展,以期为后续研究提供参考。The dynamic balance of intestinal flora is an important sign of maintainance of human health.Environment is an important factor affecting the diversity and abundance of intestinal flora.Intestinal flora can adapt to environmental changes by changing its composition.People who have lived in low-oxygen environments for generations have certain genetic changes that also affect the diversity and abundance of gut flora.The study on the correlation between hypoxic environment and intestinal flora is of great significance to the health of people in hypoxic environment.At present,the specific mechanism of the effect of hypoxic environment on intestinal flora composition has not been reported.In this paper,the changes of human intestinal flora and the possible causes in low oxygen environment at high altitude are reviewed,in order to provide reference for subsequent research.

关 键 词：肠道菌群 高原 低氧 影响因素 菌群多样性 

分 类 号：R363[医药卫生—病理学]