Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials  

作　　者：Zifan Zhao Qin Zhao Hu Chen Fanfan Chen Feifei Wang Hua Tang Haibin Xia Yongsheng Zhou Yuchun Sun 

机构地区：[1]Center of Digital Dentistry,Faculty of Prosthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China [2]The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine,Ministry of Education,School&Hospital of Stomatology,Wuhan University,Wuhan,China [3]Institute of Infection and Immunity,Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,China

出　　处：《International Journal of Oral Science》2023年第3期411-421,共11页国际口腔科学杂志（英文版）

基　　金：supported by the Beijing Training Project for the Leading Talents in S&T(Grant No.Z191100006119022);the National Key Program of the National Natural Science Foundation of China(Grant No.51705006);Capital’s Funds for Health Improvement and Research(2022-2Z-4106).

摘　　要：Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects.Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials.Previous studies have mainly focused on innate immune cells such as macrophages.In our previous work,we found that T lymphocytes,as adaptive immune cells,are also essential in the osteoinduction procedure.As the most important antigen-presenting cell,whether dendritic cells(DCs)can recognize non-antigen biomaterials and participate in osteoinduction was still unclear.In this study,we found that surgical trauma associated with materials implantation induces necrocytosis,and this causes the release of high mobility group protein-1(HMGB1),which is adsorbed on the surface of bone substitute materials.Subsequently,HMGB1-adsorbed materials were recognized by the TLR4-MYD88-NFκB signal axis of dendritic cells,and the inflammatory response was activated.Finally,activated DCs release regeneration-related chemokines,recruit mesenchymal stem cells,and initiate the osteoinduction process.This study sheds light on the immune-regeneration process after bone substitute materials implantation,points out a potential direction for the development of bone substitute materials,and provides guidance for the development of clinical surgical methods.

关 键 词：IMPLANTATION BIOMATERIALS release 

分 类 号：R318.08[医药卫生—生物医学工程]