头颈部肿瘤放疗相关口腔并发症和治疗  

Radiotherapy for head and neck cancer:oral complications and treatment

作　　者：王植 潘莹紫 陈铭晟 王锋超 Wang Zhi;Pan Yingzi;Chen Mingsheng;Wang Fengchao(State Key Laboratory of Trauma and Chemical Poisoning,Stomatological Hospital of Chongqing Medical University,Institute of Nuclear Protection Medicine,Department of Military Preventive Medicine,Basic Medical School of the Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学基础医学院,重庆医科大学附属口腔医院,陆军军医大学军事预防医学系,防原医学教研室创伤与化学中毒全国重点实验室,重庆400038

出　　处：《中华放射医学与防护杂志》2023年第9期752-758,共7页Chinese Journal of Radiological Medicine and Protection

基　　金：重庆市科技创新专项(cstc2018jcyj-yszxX0004);重庆市自然科学基金(cstc2021jcyj-msxmX0237);重庆市教育委员会科学技术研究项目(KJQN2021OO444)。

摘　　要：放疗是头颈部肿瘤患者常见的治疗方式。头颈部放疗常会导致口腔颌面部并发症,因该部位组织结构复杂,发病机制多样,现有的治疗方案和研究进展较为局限。本文重点对最常见的放射性口腔黏膜炎、放射性唾液腺损伤及放射性龋齿进行系统总结,回顾了现有发病机制假说、治疗及研究进展,以期为深入研究相关病理机制和新的预防、治疗手段提供一定的参考。Radiotherapy,as a common modality for the treatment of head and neck cancer(HNC),frequently induces oral and maxillofacial complications.However,the complex tissues and diverse pathogeneses of these regions lead to limited treatment protocols and research progress currently.This paper systematically summarizes radiation-induced oral mucositis,salivary gland injury,and dental caries in radiotherapy for HNC and reviews existing pathogenetic hypotheses,treatment,and research progress.The purpose is to provide some reference for further research on relevant pathological mechanisms and the development of new preventive and treatment methods.

关 键 词：头颈部肿瘤 放疗 口腔黏膜 唾液腺 龋齿 

分 类 号：R739.91[医药卫生—肿瘤] R818[医药卫生—临床医学]