Hevin/SPARC在中枢神经系统突触形成/重塑中的作用机制研究进展  

Recent advance in mechanism of Hevin/SPARC in central nervous system synaptogenesis/reorganization

作　　者：王尧[1] 韩兴月 徐菁[1] 陈欣 余思逊 树海峰 Wang Yao;Han Xingyue;Xu Jing;Chen Xin;Yu Sixun;Shu Haifeng(Institute of Biomedical Engineering,School of Medicine,Southwest Jiaotong University,Chengdu 610031,China;Department of Neurosurgery,General Hospital of Western Theater Command,Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]西南交通大学医学院生物医学工程研究院,成都610031 [2]西南交通大学附属医院,西部战区总医院神经外科,成都610031

出　　处：《中华神经医学杂志》2023年第9期937-941,共5页Chinese Journal of Neuromedicine

摘　　要：高内皮静脉蛋白(Hevin)是星型胶质细胞分泌的细胞外基质蛋白之一。生理条件下,Hevin在中枢神经系统突触形成方面起着重要作用,而富含半胱氨酸的酸性分泌蛋白(SPARC)是其同源物,拮抗着Hevin的促突触形成作用。病理条件下,Hevin和SPARC的表达发生变化,在多种中枢神经系统疾病如脑外伤、阿尔茨海默病、癫痫、脑肿瘤等的突触重塑中可能发挥着重要作用,但目前对此具体情况及作用机制尚不完全了解。本文现围绕Hevin/SPARC在中枢神经系统突触形成/重塑中的作用机制以及其可能对中枢神经系统疾病的作用研究进展进行综述,以期为进一步的相关研究开展提供思路。Hevin is one of the extracellular matrix proteins secreted by astrocytes.Under physiological conditions,Hevin plays an important role in synaptogenesis in the central nervous system(CNS);secreted protein,acidic and rich in cysteine(SPARC)is its homologue and antagonizes the synaptogenic effects of Hevin.In pathological conditions,the expressions of Hevin and SPARC are altered,suggesting their possible roles at synaptic reorganization in various disease process,such as brain injury,Alzheimer's disease,epilepsy and brain tumors;however,the specific mechanism is not totally understood yet.So this paper reviews the mechanism of Hevin/SPARC in CNS synaptogenesis,reorganization and diseases to provide ideas for further research.

关 键 词：高内皮静脉蛋白 富含半胱氨酸的酸性分泌蛋白 突触形成 突触重塑 中枢神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]