TDP-43病理蛋白在阿尔茨海默病诊疗中的研究进展  

Recent advance in TDP-43 proteinopathy in diagnosing and treating Alzheimer's disease

作　　者：金宏福 孙慧 郭沈睿 冯奕源 尹雅芙 王辉[1] 程维维[1] Jin Hongfu;Sun Hui;Guo Shenrui;Feng Yiyuan;Yin Yafu;Wang Hui;Cheng Weiwei(Department of Nuclear Medicine,Xinhua Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院核医学科,上海200092

出　　处：《中华神经医学杂志》2023年第9期942-946,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81901162);上海市科学技术委员会(20QA1406300,23ZR1441200)。

摘　　要：TDP-43病理蛋白在阿尔茨海默病(AD)中的重要作用正被逐歩揭示。近半数AD患者TDP-43病理蛋白阳性,并与患者海马萎缩及认知功能障碍严重程度呈正相关,提示TDP-43病理蛋白可能是AD的重要诊疗靶点,及时评估AD患者脑内TDP-43病理蛋白情况,对AD的诊断、药物研发及治疗将产生巨大影响。本文就TDP-43病理蛋白在AD中的病理表现,以及以TDP-43病理蛋白为靶点对AD进行诊疗方面的研究进展进行综述。The important role of TDP-43 proteinopathy in Alzheimer's disease(AD)has been gradually revealed.High proportion of AD patients have TDP-43 proteinopathy on their postmortem diagnosis.Patients with TDP-43 proteinopathy show more sever hippocampal atrophy and cognitive dysfunction,suggesting that TDP-43 proteinopathy can serve as an important target in AD diagnosis and treatment.Evaluation of TDP-43 proteinopathy in vivo would hold great promise in AD diagnosis,drug development and treatment.In this review,we describe the pathological characteristics of TDP-43 proteinopathy in AD,and summarize the recent progress of TDP-43 proteinopathy in the diagnosis and treatment of AD.

关 键 词：阿尔茨海默病 TDP-43病理蛋白 边缘为主年龄相关TDP-43脑病 影像学诊断 

分 类 号：R749.16[医药卫生—神经病学与精神病学]