加味桔梗枳壳汤对胃食管反流病患者食管运动功能及胃肠激素水平的影响  

Effect of modified Jiegeng Zhike decoction on the esophageal motility and the levels of gastrointestinal hormones in patients with gastroesophageal reflux disease

作　　者：于鲲[1] 张广玉[1] 党中勤[1] 孙晓娜[1] 吴秋霞[1] YU Kun;ZHANG Guangyu;DANG Zhongqin;SUN Xiaona;WU Qiuxia(Department of Liver,Gallbladder,Spleen and Stomach Diseases,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450003,China)

机构地区：[1]河南省中医院肝胆脾胃病科,郑州450003

出　　处：《吉林中医药》2023年第10期1174-1178,共5页Jilin Journal of Chinese Medicine

基　　金：国家中医药管理局中医药循证能力建设项目(2019XZZX-XH005)。

摘　　要：目的 探讨加味桔梗枳壳汤对胃食管反流病患者食管运动功能及胃肠激素水平的影响。方法 按随机数字表法分配原则将60例2021年6月-2022年6月河南省中医院肝胆脾胃病科收治的胃食管反流病患者分为对照组(30例)和治疗组(30例)。对照组给予雷贝拉唑钠肠溶片进行治疗,治疗组在对照组基础上给予加味桔梗枳壳汤进行治疗,2组均持续治疗8周。比较2组治疗8周后的疗效,治疗前、治疗8周后的临床症状改善情况、食管运动功能、胃肠激素、疾病相关因子及治疗期间的安全性。结果 与对照组比较,治疗组治疗8周后的总有效率较高(P <0.05)。与治疗前比较,2组治疗8周后的反食、反酸、烧心、非心源性胸痛评分、食管体部上段和下段非传导波、反向蠕动波、血清血管活性肠肽(VIP)、5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)、P物质(SP)水平均降低,治疗组低于对照组(P <0.05);2组食管体部上段和下段蠕动波压力、顺行性蠕动波、血清胃动素(MTL)、胃泌素(GAS)水平均升高,治疗组高于对照组(P <0.05);治疗组治疗期间的不良反应总发生率为6.67%,与对照组(13.33%)比较,差异无统计学意义(P> 0.05)。结论 加味桔梗枳壳汤可有效调节胃食管反流病患者疾病相关因子和胃肠激素水平,改善胃肠功能,并可改善患者食管运动功能,进而可促进临床症状的缓解,疗效显著,且安全性良好。Objective To investigate the effect of modified Jiegeng Zhike decoction on the esophageal motility and the levels of gastrointestinal hormones in patients with gastroesophageal reflux disease.Methods A total of 60 patients with gastroesophageal reflux disease admitted to the department of liver,gallbladder,spleen and stomach diseases of Henan Provincial Hospital of Traditional Chinese Medicine from June 2021 to June 2022 were divided into a control group(30 cases)and a treatment group(30 cases)according to the distribution principle of random number table.The control group was treated with rabeprazole sodium enteric coated tablets,while the treatment group was treated with the modified Jiegeng Zhike decoction on the basis of the control group.Both groups were treated for 8 weeks.The efficacy after 8 weeks of treatment,the improvement of clinical symptoms,esophageal motor function,gastrointestinal hormones,disease related factors before and after 8 weeks of treatment,and the safety during treatment of the two groups were compared.Results Compared with the control group,the total effective rate of the treatment group was higher after 8 weeks of treatment(P<0.05).Compared with those before treatment,the scores of regurgitation,acid regurgitation,heartburn,noncardiac chest pain,nonconducted waves,reverse peristalsis waves in the upper and lower segments of the esophagus,serum levels of vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT),calcitonin gene related peptide(CGRP),substance P(SP)were decreased in the two groups after 8 weeks of treatment,and those in the treatment group were lower than those in the control group(P<0.05);the peristaltic wave pressure,anterograde peristaltic wave in the upper and lower segments of the esophagus,serum levels of motilin(MTL)and gastrin(GAS)were increased in the two groups,and those in the treatment group were higher than those in the control group(P<0.05).The total incidence of adverse reactions during treatment in the treatment group was 6.67%,which was not statisti

关 键 词：胃食管反流病 加味桔梗枳壳汤 雷贝拉唑钠肠溶片 食管运动功能 胃肠激素 疾病相关因子 安全性 

分 类 号：R573[医药卫生—消化系统]